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Pregled bibliografske jedinice broj: 604173

Časopis

Autori: Okada, Y.; ...; Kolčić, Ivana; Polašek, Ozren; Zemunik, Tatijana; Boban, Mladen; Rudan, Igor; ...; Tanaka, T.
Naslov: Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
( Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations )
Izvornik: Nature genetics (1061-4036) 44 (2012); 904-909
Vrsta rada: članak
Ključne riječi: loci; kidney; Asian
( loci; kidney; Asian )
Sažetak:
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71, 149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110, 347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Projekt / tema: 216-1080315-0302
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://www.nature.com/ng/journal/v44/n8/full/ng.2352.html
Broj citata:
Altmetric:
DOI: 10.1038/ng.2352
URL cjelovitog teksta:
Google Scholar: Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Upisao u CROSBI: opolasek@mefst.hr (opolasek@mefst.hr), 20. Stu. 2012. u 16:47 sati



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