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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 604177

Časopis

Autori: Manning, A.K.; ...; Boban, Mladen; ...; Budimir, Danijela; ...; Kolčić, Ivana; ...; ...; Pehlić, Marina; ...; Peričić, Marijana; ...; Polašek, Ozren; ...; Rudan, Igor; Zelenika, Diana; Zemunik, Tatijana; Zgaga, Lina; ...; Langenberg C.
Naslov: A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
( A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance )
Izvornik: Nature genetics (1061-4036) 44 (2012); 659-669
Vrsta rada: članak
Ključne riječi: loci; SNP; insulin
( loci; SNP; insulin )
Sažetak:
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96, 496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology
Projekt / tema: 216-1080315-0302
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.nature.com/ng/journal/v44/n6/full/ng.2274.html
Broj citata:
Altmetric:
DOI: 10.1038/ng.2274
URL cjelovitog teksta:
Google Scholar: A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Upisao u CROSBI: opolasek@mefst.hr (opolasek@mefst.hr), 20. Stu. 2012. u 16:54 sati
Napomene:
Consortium DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) ; The Multiple Tissue Human Expression Resource (MUTHER) Consortium.



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