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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 604179

Časopis

Autori: Stolk, L.; ...; Barbalić, Maja; ...; Barać Lauc, Lovorka; ...; Boban, Mladen; ...; Kolčić, Ivana; ...; Martinović Klarić, Irena; ...; Polašek, Ozren; ...; Rudan, Igor; Zemunik, Tatijana; Zgaga, Lina; ...; Lunetta K.L.
Naslov: Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
( Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways )
Izvornik: Nature genetics (1061-4036) 44 (2012); 260-268
Vrsta rada: članak
Ključne riječi: menopause; loci; genetics
( menopause; loci; genetics )
Sažetak:
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38, 968 women of European descent, with replication in up to 14, 435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
Projekt / tema: 216-1080315-0302
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://www.nature.com/ng/journal/v44/n3/full/ng.1051.html
Broj citata:
Altmetric:
DOI: 10.1038/ng.1051
URL cjelovitog teksta:
Google Scholar: Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Upisao u CROSBI: opolasek@mefst.hr (opolasek@mefst.hr), 20. Stu. 2012. u 17:01 sati



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