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izvor podataka: crosbi

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (CROSBI ID 187852)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Stolk, L. ; ... ; Barbalić, Maja ; ... ; Barać Lauc, Lovorka ; ... ; Boban, Mladen ; ... ; Kolčić, Ivana ; ... et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways // Nature genetics, 44 (2012), 260-268. doi: 10.1038/ng.1051

Podaci o odgovornosti

Stolk, L. ; ... ; Barbalić, Maja ; ... ; Barać Lauc, Lovorka ; ... ; Boban, Mladen ; ... ; Kolčić, Ivana ; ... ; Martinović Klarić, Irena ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; Zemunik, Tatijana ; Zgaga, Lina ; ... ; Lunetta K.L.

engleski

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38, 968 women of European descent, with replication in up to 14, 435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

menopause; loci; genetics

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

44

2012.

260-268

objavljeno

1061-4036

10.1038/ng.1051

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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Indeksiranost