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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 604509

Časopis

Autori: Sabol, Maja; Car, Diana; Musani, Vesna; Ozretić, Petar; Orešković, Slavko; Weber, Igor; Levanat, Sonja
Naslov: The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched
( The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched )
Izvornik: International journal of oncology (1019-6439) 41 (2012), 4; 1411-1418
Vrsta rada: članak
Ključne riječi: hedgehog signaling; ovarian teratoma; cyclopamine; gene expression; confocal microscopy
( hedgehog signaling; ovarian teratoma; cyclopamine; gene expression; confocal microscopy )
Sažetak:
The Hedgehog-Gli (Hh-Gli) signaling pathway was examined in ovarian dermoids, which show characteristics of both tumors and developmental malformations. Dermoids are classified as mature teratomas that present differentiation into various tissues, mostly epidermal elements such as glands, multilayered epithelium, hair follicles and occasionally bone and cartilage. Their development is attributed to aberrant meiosis of germinal cells within the ovary. We showed activation of the Hh-Gli signaling in ovarian dermoid primary cultures. Cyclopamine treatment slows down cell proliferation, while the Sonic Hedgehog (Shh) protein stimulates cell proliferation and induces internalization of the Patched (Ptch) protein, which accumulates in the form of granules in the cytoplasm, colocalized with the Shh protein. Cyclopamine treatment decreases Gli1 localization in the nucleus compared to non-treated cells. Based on our observations, the mechanism of Hedgehog activation in the ovarian dermoids could be the ligand-dependent autocrine pathway, which can also be stimulated by paracrine signals.
Projekt / tema: 098-0982464-2461
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2311/1/2012_Sabol_Int_J_Oncol.pdf
http://www.spandidos-publications.com/ijo/41/4/1411?text=fulltext
Broj citata:
Altmetric:
DOI: 10.3892/ijo.2012.1554
URL cjelovitog teksta:
Google Scholar: The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched
Upisao u CROSBI: pozretic@irb.hr (pozretic@irb.hr), 22. Stu. 2012. u 10:12 sati



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