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Pregled bibliografske jedinice broj: 610109

Časopis

Autori: Ilijaš, Marina; Malnar, Ivica; Gabelica Marković, Vesna; Stepanić, Višnja
Naslov: Study of lipophilicity and membrane partition of 4-hydroxycoumarins by HPLC and PCA
( Study of lipophilicity and membrane partition of 4-hydroxycoumarins by HPLC and PCA )
Izvornik: Journal of pharmaceutical and biomedical analysis (0731-7085) 76 (2013); 104-111
Vrsta rada: članak
Ključne riječi: 4-hydroxycoumarins; HPLC; CHI; CHI IAM; structure-retention reletaionship
( 4-hydroxycoumarins; HPLC; CHI; CHI IAM; structure-retention reletaionship )
Sažetak:
Physicochemical properties provide reliable guidance in optimization of pharmacological efficiency and ADME profile of small chemical compounds. Their high-throughput determination is regularly based on application of HPLC techniques. In this study CHI and CHI IAM of 32 4-hydroxycoumarin analogs were measured by HPLC with methanol gradient at pHs 2.8 and 7.0. Results were analyzed by PCA in terms of computed descriptors in order to identify space for optimization of their phospholipids affinity and lipophilicity for which predictive software failed to produce reliable estimations. The chromatographic behavior of studied 4-hydroxycoumarins was typical of acidic compounds. The CHI2.8, CHI7.0, CHI IAM2.8 and CHI IAM7.0 values were all considerably cross-correlated in accordance with their prevailing lipophilic character. Structure–retention relationship (SRR) analysis furthermore revealed that H-bond accepting capacity and dipolar interactions with methanol generally shorten their retention times. However, deviations from the linear trends were noticed for R3/R5-substituted derivatives able to form intramolecular contacts with the 4-O(H) group and characterized by more uniform electron density at 2-O and 4-O atoms and quite different acidity/H-bond donating capacity than the rest of derivatives. Thus, CHI and CHI IAM determinations and SRR analysis fast and efficiently pointed to ways of modifying biological activities of 4-hydroxycoumarins.
Projekt / tema: 098-0982464-2511
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Farmacija
URL Internet adrese: http://dx.doi.org/10.1016/j.jpba.2012.11.043
http://www.sciencedirect.com/science/article/pii/S0731708512006589
http://ac.els-cdn.com/S0731708512006589/1-s2.0-S0731708512006589-main.pdf?_tid=128b6b6e-cd18-11e2-a52f-00000aab0f02&acdnat=1370351585_111984808c67f846b97cf7792d1a09ad
Broj citata:
Altmetric:
DOI: 10.1016/j.jpba.2012.11.043
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.jpba.2012.11.043
Google Scholar: Study of lipophilicity and membrane partition of 4-hydroxycoumarins by HPLC and PCA
Upisao u CROSBI: stepanic@irb.hr (stepanic@irb.hr), 7. Sij. 2013. u 08:04 sati



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