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Pregled bibliografske jedinice broj: 610630

Časopis

Autori: Fenzl, Vanja; Flegar-Meštrić, Zlata; Perkov, Sonja; Andrišić, Luka; Tatzbe, Franz; Žarković, Neven; Duić, Željko
Naslov: Trace elements and oxidative stress in hypertensive disorders of pregnancy
Izvornik: Archives of gynecology and obstetrics (0932-0067) 287 (2013), 1; 19-24
Vrsta rada: članak
Ključne riječi: hypertensive disorders of pregnancy; total oxidant capacity; total antioxidant capacity; iron; copper; zinc
Sažetak:
Purpose Due to increased metabolic requests, pregnancy can be considered as metabolic stress, especially if associated with oxidative stress triggered by disbalance of pro/antioxidants. The aim of the study was to determine serum concentrations of the trace elements iron (Fe), zinc (Zn) and copper (Cu) important in growth regulation and pro/antioxidant homeostasis, in relation to the total serum oxidant capacity (TOC) and total serum antioxidant capacity (TAC) in pregnant women with preeclampsia (n = 30) or with gestational hypertension (n = 30) and in healthy pregnant women (n = 37) and non-pregnant women (n = 30) as control groups expecting common differences between all pregnant women and controls and between preeclampsia and the other pregnancies indicating specific disbalance of the oxidative stress and analyzed trace elements. Methods Serum Fe was determined by spectrophotometric method, Cu and Zn were determined by atomic absorption spectrometry, TOC was determined by Enzymatic ANTIOX-CAP assay and TAC by Peroxide-activity assay. Results Serum Cu and TOC were significantly higher while Zn was lower in all pregnant groups regardless of hypertensive disorders. Serum Fe and TAC concentrations were found to be significantly higher in pregnant women with preeclampsia compared to pregnant controls. Conclusion Increase of TOC in all pregnant women our study points to latent oxidative stress in pregnancy. Fe might have a role in etiopathogenesis of preeclampsia while the increase of TAC in the very beginning of preeclampsia might represent a stressdefence mechanism of the body. It has still to be revealed whether significantly higher serum Fe levels are associated with preeclampsia as a cause or as a consequence of this disorder.
Projekt / tema: 098-0982464-2519, 044-0061245-0551
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://link.springer.com/article/10.1007%2Fs00404-012-2502-4
Broj citata:
Altmetric:
DOI: 10.1007/s00404-012-2502-4
URL cjelovitog teksta:
Google Scholar: Trace elements and oxidative stress in hypertensive disorders of pregnancy
Upisao u CROSBI: zmes@kb-merkur.hr (zmes@kb-merkur.hr), 8. Sij. 2013. u 20:56 sati



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