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Pregled bibliografske jedinice broj: 617460

Časopis

Autori: Musani, Vesna; Sabol, Maja; Car, Diana; Ozretić, Petar; Kalafatić, Držislav; Maurac, Ivana; Orešković, Slavko; Levanat, Sonja
Naslov: PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele
( PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele )
Izvornik: Gene (0378-1119) 517 (2013), 1; 55-59
Vrsta rada: članak
Ključne riječi: PTCH1; polymorphism; LOH; ovarian tumors
( PTCH1; polymorphism; LOH; ovarian tumors )
Sažetak:
In this study we investigated the types and role of different genetic changes of PTCH1 gene in three different types of ovarian tumors: carcinomas, fibromas and dermoids. LOH of the PTCH1 region was detected in 27.3% ovarian carcinoma samples, 18.18% ovarian fibroma samples and 55.56% ovarian dermoid samples. No point mutations were detected in any of the three types of ovarian tumors. SNP c.3944C>T showed significant differences between ovarian carcinoma and control samples with the minor T allele being significantly higher in controls compared to ovarian carcinomas. Interestingly, a new polymorphism c.−1184G>A was found only in tumor samples and further analyses should be performed in order to elucidate its potential role in ovarian tumors.
Projekt / tema: 098-0982464-2461
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.1016/j.gene.2012.12.089
http://www.sciencedirect.com/science/article/pii/S0378111912016484
Broj citata:
Altmetric:
DOI: 10.1016/j.gene.2012.12.089
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.gene.2012.12.089
Google Scholar: PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele
Upisao u CROSBI: Petar Ozretić (Petar.Ozretic@irb.hr), 7. Vel. 2013. u 16:24 sati



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