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Pregled bibliografske jedinice broj: 62840

Časopis

Autori: Žalac, Suzana; Khan M.Z.I.; Gabelica, Vesna; Tudja, Marijan; Meštrović, Ernest.; Romih, Mira
Naslov: Paracetamol-Propyphenazone Interaction and Formulation Difficulties associated with Eutetic Formation in Combination Solid Dosage Forms
( Paracetamol-Propyphenazone Interaction and Formulation Difficulties associated with Eutetic Formation in Combination Solid Dosage Forms )
Izvornik: Chemical and pharmaceutical bulletin (0009-2363) 47 (1999), 3; 302-305
Vrsta rada: članak
Ključne riječi: Paracetamol-Propyphenazone; Eutetic Formation; Combinationon Solid Dosage Forms
( Paracetamol-Propyphenazone; Eutetic Formation; Combinationon Solid Dosage Forms )
Sažetak:
Polymorphic behaviours of paracetamol and propyphenazone and interaction between these two compounds were investigated using differential scanning calorimetry (DSC), X-ray powder diffraction and Fourier transform-infrared (FT-IR)-spectroscopy. Binary mixtures containing various ratios of the compounds were prepared as physical and fused mixtures and analysed by DSC to study their thermal behaviours. Phase diagrams obtained from the melting endotherms of the binary mixtures demonstrated formation of an eutectic mixture at a paracetamol-propyphenazone combination of about 35 : 65 (w/w) with an eutectic temperature of 56°C. The FT-IR spectroscopy revealed no chemical interaction due to eutectic formation, and a lower degree of crystallinity of the eutectic mixture than individual substances was observed by X-ray powder diffraction analysis. The DSC and X-ray powder diffraction data demonstrated a polymorphic change in propyphenazone as a result of melting of the compound. Tablets, containing both paracetamol and propyphenazone in a combination formulation and prepared using standard wet granulation technology, were found to have physical instability when packed in either polyvinylchloride//aluminium or polyvinylchloride/polyvinyldienechloride//aluminium blisters and stored for one month at 40°C with either 75% relative humidity or without any humidity control. The instability of the tablets was more apparent under the high humidity condition.
Projekt / tema: 119404
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://dx.doi.org/10.1248/cpb.47.302
https://www.jstage.jst.go.jp/article/cpb1958/47/3/47_3_302/_article
http://dx.doi.org/10.1248/cpb.47.302
Broj citata:
Altmetric:
DOI: 10.1248/cpb.47.302
URL cjelovitog teksta: http://dx.doi.org/10.1248/cpb.47.302
Google Scholar: Paracetamol-Propyphenazone Interaction and Formulation Difficulties associated with Eutetic Formation in Combination Solid Dosage Forms



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