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Pregled bibliografske jedinice broj: 629264

Časopis

Autori: Markić, Joško; Jerončić, Ana; Polančec, Denis; Bošnjak, Nada; Markotić, Anita; Meštrović, Julije; Čikeš Čulić, Vedrana
Naslov: CD15s is a potential biomarker of serious bacterial infection in infants admitted to hospital
Izvornik: European journal of pediatrics (0340-6199) 172 (2013), 10; 1363-1369
Vrsta rada: članak
Ključne riječi: infant; infection; biomarkers; CD15s; CD11b; CD64
Sažetak:
Early recognition of serious bacterial infection (SBI) in children is essential for better treatment outcome. Flow cytometry analysis of neutrophil surface molecules has been more frequently utilized as a tool for diagnosis of infection. The infants (n=105) under 6 months of age presenting to the pediatric emergency department with fever without apparent source who were hospitalized with suspicion of having SBI were enrolled in this prospective study. Sixty- nine infants were included into the training pool and were classified into bacterial or viral infection group. Validation pool consisted of 36 infants. The values of white blood cells counts, absolute neutrophil count (ANC), C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD11b, CD15s and CD64 expression, percentage (%CD15s+) and the absolute count (AC- CD15s+) of CD15s+ neutrophils were determined. In the infants with SBI, %CD15s+ was 10.5 times more likely to be higher than the cut-off value. ANC, CRP, PCT, CD64, and AC-CD15s+ were also found as useful biomarkers for differentiation between bacterial and viral infection. Thebest- fit multivariate logistic regression model included CRP, PCT, and %CD15s+ as strong predictors of SBI. The model's sensitivity (87%) and specificity (83%) indicated high model's accuracy. After validation on independent dataset, model's accuracy maintained high: 86% sensitivity and 93% specificity, confirming its reliability and supporting CRP, PCT, and %CD15s+ as real predictors. Conclusion: The findings of this study support assumption made in the literature on significance of CD15s in inflammation processes. Also, this study demonstrated for the first time that CD15s is potentially valuable biomarker of SBI in infants.
Projekt / tema: 216-2160133-0066
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Farmacija
Puni text rada: 629264.Markic_et_al2013.pdf (tekst priložen 6. Srp. 2013. u 13:22 sati)
URL Internet adrese: http://link.springer.com/article/10.1007%2Fs00431-013-2047-y
Broj citata:
Altmetric:
DOI: 10.1007/s00431-013-2047-y
URL cjelovitog teksta:
Google Scholar: CD15s is a potential biomarker of serious bacterial infection in infants admitted to hospital
Upisao u CROSBI: Joško Markić (josko.markic@mefst.hr), 15. Svi. 2013. u 14:37 sati



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