engleski

Renal cell carcinoma with clear cell and papillary features: a report of two distinctive cases

Renal cell carcinomas composed of clear cell and papillary features are rare tumors that commonly present a diagnostic challenge. Herein, we report on two cases of these tumors. 10 According to the 2004 World Health Organization classification of renal tumors, these cases were diagnosed as unclassified renal cell carcinoma composed of both clear cell and papillary renal cell carcinoma. First case was a 61-year-old woman and the second was a 56-year-old man who underwent radical nephrectomy due to a renal tumor mass. Histologically, both tumors were composed of papillary and tubular structures lined with a single layer of atypical cuboidal epithelial cells with uniform nuclei and prominent nucleoli. Solid growths of epithelial cells with clear cell cytoplasm and low grade nuclei were also noted. In second case, the tumor invaded renal pelvis, ureter and renal perihilar fat. Histologically, it also had interspersed psammoma bodies and atypical epithelial cells with abundant eosinophilic cytoplasm, and a high nuclear grade. Renal cell carcinomas presenting with clear cell and papillary features require careful morphological, immunohistochemical and, in some cases, molecular genetic examination, in order to make the correct diagnosis. These tumors have distinct biologic behaviors, and in recent literature they are proposed as new entities, clear cell papillary renal carcinomas.

renal cell carcinoma

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