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Pregled bibliografske jedinice broj: 634405

Zbornik radova

Autori: Gršković, Branka; Zidkova, Anastassiya; Stenzl, Vlastimil; Popović, Maja; Primorac, Dragan; Mršić, Gordan
Naslov: GENETIC CHARACTERIZATION OF CENTRAL CROATIA POPULATION USING MENTYPE® ARGUS X-8 KIT
Izvornik: PROGRAM AND ABSTRACTS THE EIGHTH ISABS CONFERENCE IN FORENSIC, ANTHROPOLOGIC AND MEDICAL GENETICS AND MAYO CLINIC LECTURES IN TRANSLATIONAL MEDICINE / Stanimir Vuk-Pavlović, Dragan Primorac, Moses Schanfield (ur.). - Split : International Society for Applied Biological Sciences (ISABS) , 2013. 170-170 (ISBN: 978-953-57695-0-7).
Skup: The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine
Mjesto i datum: Split, Hrvatska, 24-28.06. 2013.
Ključne riječi: Genetic characterization; Central Croatia population; The Mentype® Argus X-8; Forensic crime scene; X chromosome
Sažetak:
The new hot target on forensic crime scene is the X chromosome. The aim was to analyze 8 X-linked short tandem repeat (STR) markers in central Croatian population and to evaluate forensic efficiency of used X-STR markers. We carried out a statistical analysis of the data from previously performed genetic analyses collected during routine forensic work by the Forensic Science Centre ‘‘Ivan Vučetić’’. The Mentype® Argus X-8 PCR amplification kit was used for typing 99 unrelated healthy women and 78 men from central Croatia. Haplotype frequencies were calculated only in male samples. Arlequin 3.5 software was used to assess Hardy- Weinberg equilibrium (HWE), linkage disequilibrium (LD), observed (Ho) and expected heterozygosity (He). Power of discrimination (PD) for males and females, polymorphism information content (PIC), power of exclusion (PE), mean exclusion chance (MEC) for deficiency cases, normal trios and duos were determined using online database ChrX-STR.org. In female samples deviations from HWE (P>0.00625) for each locus were not found. LD test performed both on female and male samples, revealed no significant association between markers (P>0.00178). In 78 men, 37, 30, 35 and 30 haplotypes were found for four linkage groups. Locus DXS10135 was the most polymorphic (PIC=0.9306). PD varied from 0.6922 to 0.9345 in male and from 0.8447 to 0.9918 in female samples. Combined PD reached 99.999999% in males and 99.9999999999% in females. To our knowledge, this is the first population study based on X-STR analysis in Croatia. Further studies are needed to get an overview of the X-STR variability in Croatia.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 053-0532265-2255
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://www.isabs.hr/PDF/2013/ISABS-2013_book_of_abstracts.pdf
Upisao u CROSBI: Gordan Mršić (Gordan.Mrsic@public.carnet.hr), 26. Lip. 2013. u 12:03 sati



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