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Pregled bibliografske jedinice broj: 636364

Časopis

Autori: Perić, Zinaida; Tambić-Andrašević, Arjana; Mrzljak, Anna; Košuta, Iva; Kovačević, Višnja; Guštin, Denis; Vrhovac, Radovan
Naslov: Infekcije krvotoka u bolesnika nakon transplantacije jetre ili krvotvornih matičnih stanica
( Bloodstream infections after liver and hematopoietic stem cell transplantation )
Izvornik: Acta medica Croatica (1330-0164) 66 (2012); 365-373
Vrsta rada: članak
Ključne riječi: sepsa; transplantacija jetre; transplantacija krvotvornih matičnih stanica; antimikrobna rezistencija
( sepsis; liver transplantation; stem cell transplantation; antimicrobial resistance )
Sažetak:
The aim of this retrospective study was to evaluate and compare the incidence, timing and etiology of bloodstream infections (BSIs) in patients treated with liver- (LT) or hematopoietic stem cell transplantation (HSCT) in a single institution. We evaluated 280 consecutive transplantations over a period of 34 months. Our results demonstrated 84 episodes of BSIs (47 in LT patients and 37 in HSCT patients) at a median of 28 days post-transplantation. Relative incidence of 34.6 and 29.4 BSI episodes per 100 LT and HSCT patients, respectively, did not differ significantly between the two groups (p=0.52). BSIs in HSCT patients occurred significantly earlier (p=0.003) than in LT patients. The recently described reemergence of gram-negative (GN) pathogens as causative agents of BSIs in these patients was confirmed: GN bacilli were the predominant isolates in the LT group, responsible for 58.5% of BSIs and a very frequent (39%) cause of BSIs in the HSCT group. A higher incidence of resistant enterobacteriaceae producing extended spectrum beta-lactamases was found in isolates from LT patients compared to HSCT patients. In both groups, Pseudomonas aeruginosa was the most difficult to treat organism, with 57% of these isolates in LT patients and 44% in HSCT patients being resistant to carbapenems. To conclude, BSIs were confirmed to be important infectious complications of both LT and HSCT. Surveillance and analysis of bacteria causing bloodstream and other serious infections in transplanted patients remain the main prerequisites for planning interventions regarding prevention and treatment of infections in these patients.
Projekt / tema: 108-0000000-3455, 108-1081873-1893, 143-1080002-0101, 108-1081872-1913
Izvorni jezik: hrv
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: NE
Google Scholar: Infekcije krvotoka u bolesnika nakon transplantacije jetre ili krvotvornih matičnih stanica
Upisao u CROSBI: Anna Mrzljak (amrzljak@mef.hr), 9. Srp. 2013. u 12:48 sati



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