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Pregled bibliografske jedinice broj: 638984

Časopis

Autori: Bulum, Tomislav; Kolarić, Branko; Prkačin, Ingrid; Duvnjak, Lea
Naslov: Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients
Izvornik: Collegium antropologicum (0350-6134) 37 (2013), 3; 771-776
Vrsta rada: članak
Ključne riječi: type 1 diabetes; serum lipids; renal function; glomerular filtration rate
Sažetak:
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We investigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 ml/min per 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r=-0.21, -0.18, and -0.17, respectively, for all p <0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL cholesterol (2.9 vs 2.8 and 2.4 mmol/L). We have detected an association between eGFR and lipid abnormalities in type 1 diabetes in early stages. The study was conducted in patients with no therapeutic intervention. This may suggest that lipid abnormalities may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=174706
URL cjelovitog teksta:
Google Scholar: Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients
Upisao u CROSBI: Tomislav Bulum (tbulum@idb.hr), 7. Kol. 2013. u 18:20 sati



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