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Pregled bibliografske jedinice broj: 650778

Časopis

Autori: Žarković, Neven; Čipak, Ana; Jaganjac, Morana; Borović, Suzana; Žarković, Kamelija
Naslov: Pathophysiological relevance of aldehydic protein modifications
Izvornik: Journal of proteomics (1874-3919) 92 (2013); 239-247
Vrsta rada: članak
Ključne riječi: 4-Hydroxy-2-nonenal (HNE); Acrolein (ACR); Immunochemistry; Malondialdehyde (MDA); Non-enzymatic protein modifications; Oxidative stress
Sažetak:
There is growing body of evidence that oxidative stress, i.e. excess in production of reactive oxygen species, can lead to covalent modification of proteins with bioactive aldehydes that are mostly produced under lipid peroxidation of polyunsaturated fatty acids. Thus generated reactive aldehydes are considered as second messengers of free radicals because they react with major bioactive macromolecules, in particular with various humoral and cellular proteins changing their structure and functions. Therefore, the aldehydic-protein adducts, in particular those involving 4-hydroxy-2-nonenal, malondialdehyde and acrolein can be valuable biomarkers of numerous pathophysiological processes. The development of immunochemical methods is increasing the possibilities to study such non-enzymatic protein modifications, on the one hand, while on the other hand the increase of knowledge on bioactivities of the aldehydes and their protein adducts might lead to better prevention, diagnosis and treatments of pathophysiological processes associated with lipid peroxidation and oxidative stress in general.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://ac.els-cdn.com/S1874391913000663/1-s2.0-S1874391913000663-main.pdf?_tid=0d9a46b6-76f4-11e4-9755-00000aab0f27&acdnat=1417175310_b03367b32f8ea5c49219095e74f48df2
http://www.sciencedirect.com/science/article/pii/S1874391913000663
Broj citata:
Altmetric:
DOI: 10.1016/j.jprot.2013.02.004
URL cjelovitog teksta:
Google Scholar: Pathophysiological relevance of aldehydic protein modifications
Upisao u CROSBI: Marina Cindrić (Marina.Cindric@irb.hr), 30. Lis. 2013. u 08:18 sati



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