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Pregled bibliografske jedinice broj: 650802

Časopis

Autori: Vistoli, G.; De Maddis, D.; Čipak, Ana; Žarković, Neven; Carini, M.; Aldini, G.
Naslov: Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation
Izvornik: Free radical research (1071-5762) 47 (2013), S1; 3-27
Vrsta rada: pregledni rad
Ključne riječi: advanced glycation end products ; advanced lipoxidation end products ; AGEs ; ALEs ; protein carbonylation ; reactive carbonyls species
Sažetak:
Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders. AGEs and ALEs represent a quite complex class of compounds that are formed by different mechanisms, by heterogeneous precursors and that can be formed either exogenously or endogenously. There is a wide interest in AGEs and ALEs involving different aspects of research which are essentially focused on set-up and application of analytical strategies (1) to identify, characterize, and quantify AGEs and ALEs in different pathophysiological conditions ; (2) to elucidate the molecular basis of their biological effects ; and (3) to discover compounds able to inhibit AGEs/ALEs damaging effects not only as biological tools aimed at validating AGEs/ALEs as drug target, but also as promising drugs. All the above-mentioned research stages require a clear picture of the chemical formation of AGEs/ALEs but this is not simple, due to the complex and heterogeneous pathways, involving different precursors and mechanisms. In view of this intricate scenario, the aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija
URL Internet adrese: http://fulir.irb.hr/3540/1/Advanced_glycoxidation_lipoxidation_2013_zarkovic_cipak.pdf
http://www.tandfonline.com/doi/full/10.3109/10715762.2013.815348
Broj citata:
Altmetric:
DOI: 10.3109/10715762.2013.815348
URL cjelovitog teksta:
Google Scholar: Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation
Upisao u CROSBI: Marina Cindrić (Marina.Cindric@irb.hr), 30. Lis. 2013. u 09:54 sati



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