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Pregled bibliografske jedinice broj: 650803

Časopis

Autori: Jaganjac, Morana; Tirosh, O.; Cohen, G.; Sasson, S.; Žarković, Neven
Naslov: Reactive aldehydes - second messengers of free radicals in diabetes mellitus
Izvornik: Free radical research (1071-5762) 47 (2013), S1; 39-48
Vrsta rada: pregledni rad
Ključne riječi: 4-hydroxydodecadienal ; 4-hydroxynonenal ; Advanced glycation end products ; Advanced lipoxidation end products ; Diabetes mellitus ; Lipid peroxidation ; PPARδ ; Reactive aldehydes ; Reactive carbonyl compounds ; Reactive oxygen species
Sažetak:
Elevated levels of pro-oxidants and various markers of oxidative tissue damage were found in diabetic patients, indicating involvement of oxidative stress in the pathogenesis of diabetes mellitus (DM). On one side, physiological levels of reactive oxygen species (ROS) play an important role in redox signaling of various cells, while on the other, excessive ROS production can jeopardize the integrity and physiological functions of cellular macromolecules, in particular proteins, thus contributing to the pathogenesis of DM. Reactive aldehydes, especially 4-hydroxynonenal (HNE), are considered as second messengers of free radicals that act both as signaling molecules and as cytotoxic products of lipid peroxidation causing long-lasting biological consequences, in particular by covalent modification of macromolecules. Accordingly, the HNE and related reactive aldehydes may play important roles in the pathophysiology of DM, both in the development of the disease and in its progression and complications due to the following: (i) exposure of cells to supraphysiological levels of 4-hydroxyalkenals, (ii) persistent and sustained generation of 4-hydroxyalkenals that progressively affect vulnerable cells that lack an efficient bioactive aldehyde neutralization system, (iii) altered redox signaling influenced by reactive aldehydes, in particular by HNE, and (iv) induction of extracellular generation of similar aldehydes under secondary pathological conditions, such as low-grade inflammation.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija
URL Internet adrese: http://fulir.irb.hr/3538/1/Reactive%20aldehydes%20second%20messengers%20of%20free%20radicals%20in%20diabetes%20mellitus.pdf
http://www.tandfonline.com/action/showCopyRight?scroll=top&doi=10.3109%2F10715762.2013.789136
Broj citata:
Altmetric:
DOI: 10.3109/10715762.2013.789136
URL cjelovitog teksta:
Google Scholar: Reactive aldehydes - second messengers of free radicals in diabetes mellitus
Upisao u CROSBI: Marina Cindrić (Marina.Cindric@irb.hr), 30. Lis. 2013. u 09:59 sati



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