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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 650825

Časopis

Autori: Krištić, Jasminka; Vučković, Frano; Menni, Cristina; Klarić, Lucija; Keser, Toma; Bečeheli, Ivona; Pučić-Baković, Maja; Novokmet, Mislav; Mangino, Massimo; Thaqi, Kujtim; Rudan, Pavao; Novokmet, Natalija; Šarac, Jelena; Missoni, Saša; Kolčić, Ivana; Polašek, Ozren; Rudan, Igor; Campbell, Harry; Hayward, Caroline; Aulchenko, Yurii; Valdes, Ana; Wilson, James F.; Gornik, Olga; Primorac, Dragan; Zoldoš, Vlatka; Spector, Tim; Lauc, Gordan
Naslov: Glycans are a novel biomarker of chronological and biological age
Izvornik: The journals of gerontology. Series A, Biological sciences and medical sciences (1079-5006) 69 (2014), 7; 779-789
Vrsta rada: članak
Ključne riječi: aging ; glycome ; glycosylation ; immunoglobulin G ; inflammation
Sažetak:
Fine structural details of glycans attached to the conserved N- glycosylation site significantly affect function of individual IgG molecules, but also mediate inflammation at the systemic level. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very complex patterns of changes of IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.
Projekt / tema: 119-1191196-1224, 006-0061194-2023, 196-1962766-2751
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Etnologija i antropologija
URL Internet adrese: http://biomedgerontology.oxfordjournals.org/content/69/7/779
http://biomedgerontology.oxfordjournals.org/content/69/7/779.full.pdf+html
Broj citata:
Altmetric:
DOI: 10.1093/gerona/glt190
URL cjelovitog teksta:
Google Scholar: Glycans are a novel biomarker of chronological and biological age
Upisao u CROSBI: Saša Missoni (Sasa.Missoni@inantro.hr), 30. Lis. 2013. u 10:50 sati



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