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Pregled bibliografske jedinice broj: 650840

Časopis

Autori: Wittine, Karlo; Poljak, Kristina; Kovač, Matea; Makuc, Damjan; Plavec, Janez; Balzarini, Jan; Martinović, Tamara; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
Naslov: The Novel [4, 5-e][1, 3]Diazepine-4, 8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole : Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations
Izvornik: Molecules (1420-3049) 18 (2013), 11; 13385-13397
Vrsta rada: članak
Ključne riječi: imidazole; [4; 5-e][1; 3]diazepine; anti-RSV; anti-tumor
Sažetak:
In the present paper, we report on the synthesis, and in vitro antiviral and cytostatic activities of a series of novel imidazole[4, 5-e][1, 3]diazepine-4, 8-dione (compounds 9–11) and acyclic carbamoyl imino-ureido imidazole (compounds 12 and 13) derivatives. These new type of chemical entities showed no significant activity on the broad spectrum of DNA and RNA viruses. Results of antiproliferative assays performed on a panel of selected human tumor cell lines revealed that only compounds 1 and 5 showed moderate and selective cytostatic effect against HeLa cells (IC50 = 24 and 32 µM) with no concomitant cytotoxic effects on human normal fibroblasts (BJ). Importantly, an imidazole derivative containing a pyrrolidine moiety linked via an ethylenic spacer (3) showed a selective cytostatic effect toward cervical carcinoma (HeLa) cells (IC50 = 9.5 µM) with no apparent cytotoxicity on human normal fibroblasts (BJ). This compound can be therefore considered as a potential anti-tumor lead compound for further synthetic structure optimization.
Projekt / tema: 335-0982464-2393, 335-0000000-3532, 125-0982464-2922
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biotehnologija
URL Internet adrese: http://www.mdpi.com/1420-3049/18/11/13385/pdf
http://www.mdpi.com/1420-3049/18/11/13385
Broj citata:
Altmetric:
DOI: 10.3390/molecules181113385
URL cjelovitog teksta: http://www.mdpi.com/1420-3049/18/11/13385/pdf
Google Scholar: The Novel [4, 5-e][1, 3]Diazepine-4, 8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole : Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations
Upisao u CROSBI: Karlo Wittine (karlo.wittine@biotech.uniri.hr), 30. Lis. 2013. u 11:34 sati



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