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Pregled bibliografske jedinice broj: 654149

Zbornik radova

Autori: Cindric, Marina; Milkovic, Lidija; Balic, Marija; Dandachi, Nadia; Cipak, Ana
Naslov: Hydroxynonenal modified extracellular matrix affects colonospheres growth
Izvornik:
Skup: COST CM1106 Working Group Meeting in Warsaw
Mjesto i datum: Varšava, Poljska, 19-20.09.2013.
Ključne riječi: hydroxynonenal; colonospheres; microenvironment; ECM
Sažetak:
Colon cancer is the third most commonly diagnosed cancer in the world, and the second most common cause of death from cancer. Most of the colon cancer deaths result from the metastatic spread of chemotherapy resistant cells mainly to the liver. Although there is increasing evidence that a rare population of tumour initiating cells is responsible for tumour formation and maintenance, their identification in human colon cancer was first published in 2007. Colon cancer stem cells (CSC) can readily be expanded by generating colonospheres from colon cancer cell lines. Still, little is known about regulation of growth and maintenance of colon CSCs. Microenvironment was shown to be important, but often disregarded factor in modulation of CSCs tumourigenicity. Abundant with proteins susceptible to different modifications, the extracellular matrix (ECM) could hide many answers to clarify cancer initiation. As an end product of lipid peroxidation, hydroxynonenal is known modulator of important cell processes (e.g. differentiation, proliferation or apoptosis). Therefore, we have investigated the effect of hydroxynonenal modified ECM derived from normal fibroblasts on growth of colonospheres and their enrichment in CSCs.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Kategorija: Znanstveni
Upisao u CROSBI: Marina Cindrić (Marina.Cindric@irb.hr), 13. Stu. 2013. u 11:09 sati



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