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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 654803

Časopis

Autori: Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Naslov: Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model
Izvornik: International journal of molecular sciences (1422-0067) 14 (2013), 12; 23654-23671
Vrsta rada: članak
Ključne riječi: colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect
Sažetak:
The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.
Projekt / tema: 119-0532265-1254, 335-0000000-3532, 335-0982464-2393, 006-0000000-3216, 098-0982464-2511, 119-0000000-1255
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2944/1/Int_J_Mol_Sci_2013_14.pdf
http://www.mdpi.com/1422-0067/14/12/23654
Broj citata:
Altmetric:
DOI: 10.3390/ijms141223654
URL cjelovitog teksta:
Google Scholar: Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model
Upisao u CROSBI: Sandra Kraljević Pavelić (sandrakp@biotech.uniri.hr), 15. Stu. 2013. u 15:57 sati



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