Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model (CROSBI ID 197685)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Šaban, Nina ; Stepanić, Višnja ; Vučinić, Srđan ; Horvatić, Anita ; Cindrić, Mario ; Perković, Ivana ; Zorc, Branka ; Oršolić, Nada ; Mintas, Mladen ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra
engleski
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model
The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.
colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect
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Podaci o izdanju
14 (12)
2013.
23654-23671
objavljeno
1422-0067
10.3390/ijms141223654
Povezanost rada
Kemija, Temeljne medicinske znanosti, Biologija