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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 659695

Časopis

Autori: Zorić, Nataša; Horvat, Igor; Kopjar, Nevenka; Vučemilović, Ante; Kremer, Dario; Tomić, Siniša; Kosalec, Ivan
Naslov: Hydroxytyrosol expresses antifungal activity in vitro
( Hydroxytyrosol expresses antifungal activity in vitro )
Izvornik: Current drug targets (1389-4501) 14 (2013); 992-998
Vrsta rada: članak
Ključne riječi: antifungal activity; Candida albicans; cell surface hydrophobicity; germ-tube formation hydroxytyrosol; virulence factors; olive leaf
( antifungal activity; Candida albicans; cell surface hydrophobicity; germ-tube formation hydroxytyrosol; virulence factors; olive leaf )
Sažetak:
Hydroxytyrosol (HT) is a potent antioxidant found in olive oil and leaves. Using several in vitro approaches, we tested antifungal activity of HT. HT showed broad spectrum of antifungal activity against medically important yeasts and dermatophyte strains with MIC values ranging between 97.6 μgml-1 and 6.25 mgml-1. The antimicrobial activity of HT was also tested using the time-kill methodology. Below the MIC value, HT showed potent damage of cell wall of Candida albicans ATCC 10231 using fluorescent dye-exclusion method. At the subinhibitory concentration, HT also influenced dimorphic transition of C. albicans indicating that HT is inhibitor of germ-tube formation as one of the most important virulence factor of C. albicans. Furthermore, HT showed disturbances in cell surface hydrophobicity (CSH) of C. albicans. The in vitro results indicate that HT caused significant cell wall damage and changes in CSH as well as inhibition of germ-tube formation as virulence factor of C. albicans. The study indicates that HT has a considerable in vitro antifungal activity against medically important yeasts.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
URL cjelovitog teksta:
Google Scholar: Hydroxytyrosol expresses antifungal activity in vitro
Upisao u CROSBI: Dario Kremer (dkremer@pharma.hr), 2. Pro. 2013. u 13:47 sati



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