crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 661778

Časopis

Autori: Marković, Darko; Katić, Jelena; Stojković, Ranko; Borović, Suzana; Žarković, Neven; Fučić, Aleksandra
Naslov: Lipid peroxidation, detoxification capacity, and genome damage in mice after transplacental exposure to pharmaceutical drugs
Izvornik: Brazilian journal of medical and biological research (0100-879X) 46 (2013), 12; 1014-1020
Vrsta rada: članak
Ključne riječi: glutathione peroxidase; malondialdehyde; genome damage; transplacental exposure
Sažetak:
Data on genome damage, lipid peroxidation, and levels of glutathione peroxidase (GPX) in newborns after transplacental exposure to xenobiotics are rare and insufficient for risk assessment. The aim of the current study was to analyze, in an animal model, transplacental genotoxicity, lipid peroxidation, and detoxification disturbances caused by the following drugs commonly prescribed to pregnant women: paracetamol, fluconazole, 5- nitrofurantoin, and sodium valproate. Genome damage in dams and their newborn pups transplacentally exposed to these drugs was investigated using the in vivo micronucleus (MN) assay. The drugs were administered to dams intraperitoneally in three consecutive daily doses between days 12 and 14 of pregnancy. The results were correlated, with detoxification capacity of the newborn pups measured by the levels of GPX in blood and lipid peroxidation in liver measured by malondialdehyde (HPLC-MDA) levels. Sodium valproate and 5-nitrofurantoin significantly increased MN frequency in pregnant dams. A significant increase in the MN frequency of newborn pups was detected for all drugs tested. This paper also provides reference levels of MDA in newborn pups, according to which all drugs tested significantly lowered MDA levels of newborn pups, while blood GPX activity dropped significantly only after exposure to paracetamol. The GPX reduction reflected systemic oxidative stress, which is known to occur with paracetamol treatment. The reduction of MDA in the liver is suggested to be an unspecific metabolic reaction to the drugs that express cytotoxic, in particular hepatotoxic, effects associated with oxidative stress and lipid peroxidation.
Projekt / tema: 098-0982464-2519, 098-0982464-2390, 022-0222148-2137
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Veterinarska medicina
URL Internet adrese: http://fulir.irb.hr/2688/1/Zarkovic_Braz%20J%20Med%20Biol%20Res_2013_46_1014.pdf
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201014&lng=en&nrm=iso&tlng=en
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201014&lng=en&nrm=iso&tlng=en
Broj citata:
Altmetric:
DOI: 10.1590/1414-431X20132814
URL cjelovitog teksta: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201014&lng=en&nrm=iso&tlng=en
Google Scholar: Lipid peroxidation, detoxification capacity, and genome damage in mice after transplacental exposure to pharmaceutical drugs
Upisao u CROSBI: Ranko Stojković (Ranko.Stojkovic@irb.hr), 7. Pro. 2013. u 10:13 sati



  Verzija za printanje   za tiskati


upomoc
foot_4