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Pregled bibliografske jedinice broj: 663397

Zbornik radova

Autori: Zarkovic, Neven; Zarkovic, Kamelija; Milkovic, Lidija; Andrisic, Luka; Borovic, Suzana; Waeg, Georg; Weber, Daniela; Bennett, Stuart J.; Griffith, Helen R.; Gune, Tilman.
Naslov: Revealing 4-hydroxynonenal-histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis
Izvornik: SFRR-Europe 2013 Abstracts, SFRR - Europe 2013 Meeting "The new era of -omics in Free Radicals in Biology and Medicine" / Kelvin J. A. Davies (ur.). - Grand Hyatt San Antonio San Antonio, TX, USA : ELSEVIER , 2013. S14-S15.
ISSN: 0891-5849
Skup: SFRR - Europe 2013 Meeting "The new era of -omics in Free Radicals in Biology and Medicine"
Mjesto i datum: Atena, Grčka, 23-25.09.2013.
Ključne riječi: lipid peroxidation; biomarker; HNE-His adducts
Sažetak:
Findings on growth regulating activities of the end-product of lipid peroxidation 4-hydroxy-2-nonenal (HNE), which acts as a “second messenger of free radicals”, overlapped with the development of antibodies specific for the aldehyde-protein adducts. These led to qualitative immunochemical determinations of the HNE presence in various pathophysiological processes and to the change of consideration of the aldehyde’s bioactivities from toxicity into cell signalling Moreover, findings of the HNE-protein adduct in various organs under physiological circumstances support the concept of “oxidative homeostasis”, which implies that oxidative stress and lipid peroxidation are not only pathological but also physiological processes. Reactive aldehydes, at least HNE, could play important role in oxidative homeostasis, while complementary research approaches might reveal the relevance of the aldehydic-protein adducts as major biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis. Aiming to join efforts in such research activities researchers interacting through the International 4-Hydroxynonenal Club acting within the SFRR-International and through networking projects of the system of the European Cooperation in Science and Technology (COST) carried validation of the methods for lipid peroxidation and further developed the genuine 4-HNE-His ELISA founding quantitative and qualitative methods for detection of 4-HNE-His adducts as valuable tool to study oxidative stress and lipid peroxidation in cell cultures, various organs and tissues and eventually for human plasma and serum analyses [1].
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Kategorija: Znanstveni
Upisao u CROSBI: Lidija Milković (Lidija.Milkovic@irb.hr), 11. Pro. 2013. u 11:10 sati



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