engleski

Maximum Entropy Production and Maximum Shannon Entropy as Germane Principles for the Evolution of Enzyme Kinetics

There have been many attempts to use optimization approaches to study the biological evolution of enzyme kinetics. Our basic assumption here is that the biological evolution of catalytic cycle fluxes between enzyme internal functional states is accompanied by increased entropy production of the fluxes and increased Shannon information entropy of the states. We use simplified models of enzyme catalytic cycles and bioenergetically important free-energy transduction cycles to examine the extent to which this assumption agrees with experimental data. We also discuss the relevance of Prigogine’s minimal entropy production theorem to biological evolution.

Maximum entropy production principle, Maximum information entropy principle, enzyme kinetics, evolution, photosynthesis, ATPase, Michaelis-Menten kinetics, bacteriorhodopsin

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