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Evolution of bacterial population: The metabolic engineering of Lactobacillus brevis (CROSBI ID 606758)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Butorac, Ana ; Cindrić, Mario ; Mrvčić, Jasna ; Bačun-Družina ; Višnja Evolution of bacterial population: The metabolic engineering of Lactobacillus brevis // The 2th International Symposium "Vera Johanides" / Kniewald ; Zlatko (ur.). Zagreb, 2013. str. 122-122

Podaci o odgovornosti

Butorac, Ana ; Cindrić, Mario ; Mrvčić, Jasna ; Bačun-Družina ; Višnja

engleski

Evolution of bacterial population: The metabolic engineering of Lactobacillus brevis

Lactic acid bacteria in particular Lactobacilli are widely used in food and pharmaceutical industries. Lactobacillus brevis occupies a diverse range of environmental niches and has various metabolic capacities. Its genomic islands are consisted of numerous functional gene cassettes, especially for carbohydrates utilization, which can be mobilized, shuffled, deleted or substituted in response to niche demands. We used laboratory evolution experiments to explore bacterial adaptation under well-defined selective pressure of prolonged stationary phase growth. Genomics analyses of L. brevis after long term-starvation indicated that cells underwent chromosomal rearrangements and plasmid loss. Furthermore, proteomics analysis revealed the key differences in metabolic pathways responsible for the existence of cells. After prolonged starvation of cells the numerous proteins engaged in glucose and amino-acid catabolizing pathways, glycerolipid metabolizing pathways, and stress-response mechanisms were all differentially expressed. Metabolomics analysis indicated that the studied cells produce less lactic acid in comparison to parental cells. The understanding of experimental evolution, such as the long-term adaptation, may facilitate new strategies for development of cell lines with advantageous traits.

Lactobacillus; evolution; long term starvation

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Podaci o prilogu

122-122.

2013.

objavljeno

Podaci o matičnoj publikaciji

The 2th International Symposium "Vera Johanides"

Kniewald ; Zlatko

Zagreb:

978-953-7076-21-4

Podaci o skupu

The 2th International Symposium "Vera Johanides"

predavanje

10.06.2013-11.06.2013

Zagreb, Hrvatska

Povezanost rada

Biotehnologija