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Pregled bibliografske jedinice broj: 684016

Časopis

Autori: Ljubin-Sternak, Sunčanica; Meštrović, Tomislav; Vilibić-Čavlek, Tatjana; Mlinarić-Galinović, Gordana; Sviben, Mario; Markotić, Alemka; Škerk, Višnja
Naslov: In vitro susceptibility of urogenital Chlamydia trachomatis strains in a country with high azithromycin consumption rate
( In vitro susceptibility of urogenital Chlamydia trachomatis strains in a country with high azithromycin consumption rate )
Izvornik: Folia microbiologica (0015-5632) 58 (2013), 5; 361-365
Vrsta rada: pregledni rad
Ključne riječi: Chlamydia trachomatis ; azithromycin
( Chlamydia trachomatis ; azithromycin )
Sažetak:
Although Chlamydia trachomatis resistance is not of great concern due to its excellent sensitivity to the currently recommended first-line antibiotics (azithromycin and doxycycline), clinical treatment failures have been reported and some of them were linked to laboratory proved resistance. The aim of this study was to determine in vitro susceptibility to azithromycin and doxycycline for 24 urogenital chlamydial strains isolated in Croatia-a country with the highest consumption of azithromycin in Europe and with very high antibiotic prescription rates. Fourteen isolates from cervical swabs, nine from male urethral swabs, and one isolate from expressed prostatic secretion were tested in McCoy cell culture system. All strains were susceptible to azithromycin and doxycycline with minimal inhibitory concentration for azithromycin and doxycycline ranging from 0.064 to 0.125 μg/mL and 0.016 to 0.064 μg/mL, and minimal chlamydicidal concentration ranging from 0.064 to 2.0 μg/mL and 0.032 to 1.0 μg/mL, respectively. Since we still lack information on whether C. trachomatis is evolving in vivo in response to antibiotic selection pressure, this kind of surveillance for resistance is essential in detecting shifts in antimicrobial susceptibilities.
Projekt / tema: 143-1080002-0050, 143-1430115-0103
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://link.springer.com/article/10.1007/s12223-012-0218-2
Broj citata:
Altmetric:
DOI: 10.1007/s12223-012-0218-2
URL cjelovitog teksta:
Google Scholar: In vitro susceptibility of urogenital Chlamydia trachomatis strains in a country with high azithromycin consumption rate
Upisao u CROSBI: Marija Fijucek (mfijucek@bfm.hr), 15. Sij. 2014. u 10:29 sati



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