Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration (CROSBI ID 203386)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Duplančić, Božidar ; Stambolija, Vasilije ; Holjevac, Jadranka ; Zemba, Mladen ; Balenović, Igor ; Drmić, Ivan Domagoj ; Šuran, Jelena ; Radić, Božo ; Filipović, Marinko ; Boban Blagaić, Alenka et al. Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration // European journal of pharmacology, 727 (2014), 75-79. doi: 10.1016/j.ejphar.2014.01.046

Podaci o odgovornosti

Duplančić, Božidar ; Stambolija, Vasilije ; Holjevac, Jadranka ; Zemba, Mladen ; Balenović, Igor ; Drmić, Ivan Domagoj ; Šuran, Jelena ; Radić, Božo ; Filipović, Marinko ; Boban Blagaić, Alenka ; Brčić, Luka ; Kolenc, Danijela ; Grabarević, Željko ; Seiwerth, Sven ; Sikirić, Predrag

engleski

Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration

Anesthetized mice or rats received intravenously 6%, 10%, 20%, 40%, 60%, 80%, 90% dextran and/or white egg (1 ml/rat or 0.15 ml/mouse) into their tails. Medication (/kg b.w., 5 ml/kg) was given intraperitoneally (BPC 157 10 µg, 1 µg, 10 ng, 10 pg/kg, chloropyramine 20 mg/kg, cimetidine 10 mg/kg intraperitoneally, alone or in combination while controls received an equivolume of saline), immediately after challenge or, alternatively, at 5 min after or 24 or 48 h before challenge. The effect was assessed at 5, 10, 20 and 30 min after dextran and/or white egg challenge. We commonly noted prominent edema involving the face, upper and lower lip, snout, paws and scrotum (presented with extreme cyanosis), poor respiration and the number of fatalities after dextran and/or white egg application. Contrary, BPC 157 regimens (10 µg, 1 µg, 10 ng, 10 pg/kg) effectively, may both prevent anaphylactoid reactions that may arise from dextran and/or white egg application and furthermore, rescue already advanced reactions when given after the challenge. Chloropyramine and cimetidine given alone were only moderately effective. When given together with BPC 157, the observed effect correlates with the strong effect of BPC 157 given alone.

pentadecapeptide BPC 157; anaphylactoid reaction; dextran; ovalbumin

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

727

2014.

75-79

objavljeno

0014-2999

10.1016/j.ejphar.2014.01.046

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost