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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 685353

Časopis

Autori: Duplančić, Božidar; Stambolija, Vasilije; Holjevac, Jadranka; Zemba, Mladen; Balenović, Igor; Drmić, Ivan Domagoj; Šuran, Jelena; Radić, Božo; Filipović, Marinko; Boban Blagaić, Alenka; Brčić, Luka; Kolenc, Danijela; Grabarević, Željko; Seiwerth, Sven; Sikirić, Predrag
Naslov: Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration
( Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration )
Izvornik: European journal of pharmacology (0014-2999) 727 (2014); 75-79
Vrsta rada: članak
Ključne riječi: pentadecapeptide BPC 157; anaphylactoid reaction; dextran; ovalbumin
( pentadecapeptide BPC 157; anaphylactoid reaction; dextran; ovalbumin )
Sažetak:
Anesthetized mice or rats received intravenously 6%, 10%, 20%, 40%, 60%, 80%, 90% dextran and/or white egg (1 ml/rat or 0.15 ml/mouse) into their tails. Medication (/kg b.w., 5 ml/kg) was given intraperitoneally (BPC 157 10 µg, 1 µg, 10 ng, 10 pg/kg, chloropyramine 20 mg/kg, cimetidine 10 mg/kg intraperitoneally, alone or in combination while controls received an equivolume of saline), immediately after challenge or, alternatively, at 5 min after or 24 or 48 h before challenge. The effect was assessed at 5, 10, 20 and 30 min after dextran and/or white egg challenge. We commonly noted prominent edema involving the face, upper and lower lip, snout, paws and scrotum (presented with extreme cyanosis), poor respiration and the number of fatalities after dextran and/or white egg application. Contrary, BPC 157 regimens (10 µg, 1 µg, 10 ng, 10 pg/kg) effectively, may both prevent anaphylactoid reactions that may arise from dextran and/or white egg application and furthermore, rescue already advanced reactions when given after the challenge. Chloropyramine and cimetidine given alone were only moderately effective. When given together with BPC 157, the observed effect correlates with the strong effect of BPC 157 given alone.
Projekt / tema: 108-1083570-3643, 108-1083570-3635
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0014299914000764
Broj citata:
Altmetric:
DOI: 10.1016/j.ejphar.2014.01.046
URL cjelovitog teksta:
Google Scholar: Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration
Upisao u CROSBI: Jelena Šuran (jsuran@vef.hr), 23. Sij. 2014. u 15:22 sati



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