crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 687814

Zbornik radova

Autori: Jankovic, Iva; Mirosevic, Nikica; Ortner Hadziabdic, Maja; Jadrijevic-Mladar Takac, Milena; Tomic, Siniša; Macolic-Sarinic, Viola; Duggan, Catherine; Bates, Ian
Naslov: THE SIGNIFICANCE OF SERIOUS ADVERSE DRUG REACTIONS (ADRs) AMONG ALL REPORTED ADRs IN CROATIA
( THE SIGNIFICANCE OF SERIOUS ADVERSE DRUG REACTIONS (ADRs) AMONG ALL REPORTED ADRs IN CROATIA )
Izvornik:
Skup: 67th FIP Congress
Mjesto i datum: Peking, Kina, 31.08-06.09.2007.
Ključne riječi: adverse drug reaction; drug-drug interaction
( adverse drug reaction; drug-drug interaction )
Sažetak:
INTRODUCTION Serious adverse drug reactions (ADRs) constitute major concerns, including both individual consequences (eg. deaths and hospitalizations) and public health expense. Several studies have been conducted to assess the importance and economic consequences of adverse drug reactions1-4. However, such work has not been previously undertaken in Croatia. AIM To describe and quantify serious ADRs among all spontaneously reported ADRs in Croatia during 2005. METHODS We performed a retrospective observational study of the ADRs in Croatia reported to the Department for Pharmacovigilance, National Agency for Medicinal Products and Medical Devices for the period from March to December 2005. Data concerning the suspected ADRs were coded using MedDRA adverse drug reaction terminology. All drugs were classified using the British National Formulary (BNF) code system. ADRs were considered serious* if one of the criteria according to the Uppsala Monitoring Centre (UMC) definition were met. This database was than searched for both, actual and potential DDIs. Actual and potential DDIs were detected with a computerized interaction detection system Drug-Reax (Thomson, Micromedex). Descriptive statistics and logistic regression using SPSS 14.0. were undertaken. RESULTS The results showed that among all the reported ADRs 32.3% refered to serious ADRs (Figure 1). The majority of these serious ADRs (70.9%) were caused by drugs used for cardiovascular system (28.2%), infections (26.2%) and central nervous system conditions (16.5%). The following drugs caused the most serious ADRs: antibacterials (24.5%), drugs affecting the renin-angiotensin system and the other antihypertensive drugs (10.8%), and cytotoxic drugs (6.9%). From this database of ADRs, polypharmacy was associated with an increased risk of experiencing a serious ADR (B=1.2 ; R2=0.025 ; p=0.08). The relationship between serious ADRs, and drug interactions were explored as well. From all serious ADRs 11.7% were due to actual interactions and 27.2% due to potential interactions (Figure 2). CONCLUSIONS This study has highlighted the importance of reporting incidences that have an effect on patient outcome. Further work is planned to thoroughly evaluate this data and to compare with subsequent years reports.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: eng
Kategorija: Ostalo
Upisao u CROSBI: Iva Mucalo (imucalo@pharma.hr), 12. Vel. 2014. u 15:38 sati



Verzija za printanje   za tiskati


upomoc
foot_4