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Pregled bibliografske jedinice broj: 695559

Časopis

Autori: Škalamera, Đani; Mlinarić-Majerski, Kata; Martin-Kleiner, Irena; Kralj, Marijeta; Wan, Peter; Basarić, Nikola
Naslov: Near-visible light generation of a quinone methide from 3-hydroxymethyl-2-anthrol
Izvornik: Journal of organic chemistry (0022-3263) 79 (2014), 10; 4390-4397
Vrsta rada: članak
Ključne riječi: quinone methide ; laser flash photolysis (LFP) ; 3-hydroxymethyl-2-anthrol ; anthrol
Sažetak:
Excitation of 2-hydroxy-3-(diphenylhydroxymethyl)anthracene (7) to S1 initiates photodehydration giving the corresponding quinone methide (QM) that was detected by laser flash photolysis (LFP) in 2, 2, 2-trifluoroethanol TFE (λ = 580 nm, τ = 690 ± 10 ns). The QM decays by protonation, giving cation (λ = 520 nm, τ = 84 ± 3 μs) which subsequently reacts with nucleophiles. The rate constants in the reactions with nucleophiles were determined by LFP, whereas the adducts were isolated via preparative photolyses. The photogeneration of QMs in the anthrol series is important for potential use in biological systems since the chromophore absorbs at wavelengths > 400 nm. Antiproliferative investigations conducted with 2-anthrol derivative 7 on three human cancer cell lines showed higher activity for irradiated cells.
Projekt / tema: 098-0982933-2911, 02.05/25
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2425/
http://pubs.acs.org/doi/abs/10.1021/jo500290y
Broj citata:
Altmetric:
DOI: 10.1021/jo500290y
URL cjelovitog teksta:
Google Scholar: Near-visible light generation of a quinone methide from 3-hydroxymethyl-2-anthrol
Upisao u CROSBI: Enidija Lukša (Enidija.Luksa@irb.hr), 30. Tra. 2014. u 14:00 sati



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