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Pregled bibliografske jedinice broj: 696239

Časopis

Autori: Saraga, Marijan; Vukojević, Katarina; Krželj, Vjekoslav; Puretić, Zvonimir; Bočina, Ivana; Glavina Durdov, Merica; Weber, Stefanie; Dworniczak, Bernd; Galešić Ljubanović, Danica; Saraga-Babić, Mirna
Naslov: Mechanism of cystogenesis in nephrotic kidneys: a histopathological study
( Mechanism of cystogenesis in nephrotic kidneys: a histopathological study )
Izvornik: BMC Nephrology (1471-2369) 15 (2014);
Vrsta rada: članak
Ključne riječi: Nephrotic kidney; Cystogenesis; CNF; FSGS; Cell proliferation; Primary cilia; Apoptosis
( Nephrotic kidney; Cystogenesis; CNF; FSGS; Cell proliferation; Primary cilia; Apoptosis )
Sažetak:
Background: Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure and function and promotes cystogenesis in congenital nephrotic syndrome of the Finnish type (CNF) and focal segmental glomerulosclerosis (FSGS). Methods: CNF kidneys were analyzed genetically. Proliferation (Ki- 67), apoptosis (caspase-3), and primary cilia (α-tubulin) length and structure were analyzed immunohistochemically and ultrastructurally in healthy, CNF and FSGS kidneys. Cyst diameters were measured and correlated with proliferation index. Results: Proximal tubules cells of healthy kidneys did not proliferate. In nephrotic kidneys, tubules with apparently normal diameter covered by cuboidal/columnar epithelium (PTNC) contained 81.54% of proliferating cells in CNF and 36.18% in FSGS, while cysts covered with columnar epithelium (CC) contained 37.52% of proliferating cells in CNF and 45.23% in FSGS. The largest cysts, covered with squamous epithelium (CS) had 11.54% of proliferating cells in CNF and 13.76% in FSGS. Increase in cysts diameter correlated with changes in proliferation index, tubular cells shape, primary cilia formation and appearance of apoptotic cells. Conclusions: We present a novel histopathological data on the structure and possible changes in function of tubular cell in NS kidneys during cystogenesis. We suggest existence of common principles of cystogenesis in CNF and FSGS kidneys, including serious disturbances of tubular cells proliferation and apoptosis, and faulty primary cilia signaling leading to deterioration of proteinuria in NS kidneys.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Broj citata:
Altmetric:
DOI: 10.1186/1471-2369-15-3
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Mechanism of cystogenesis in nephrotic kidneys: a histopathological study
Upisao u CROSBI: Ivana Bočina (bocina@pmfst.hr), 8. Svi. 2014. u 13:05 sati



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