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Zbornik radova

Autori: Mandić, Leo; Mlinarić-Majerski, Kata; Basarić, Nikola
Naslov: Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity
Izvornik: MACROCYCLES - synthesis, medicinal chemistry and biological activityZagreb :
Skup: MACROCYCLES - synthesis, medicinal chemistry and biological activity
Mjesto i datum: Zagreb, Hravtska, 28-29-04-2014.
Ključne riječi: adamantanes; benzazepines; photochemistry; biological activity
Sažetak:
Various aza-heterocyclic compounds show biological activity. For example, pyrrolo[1, 4]benzodiazepines show highly selective binding to DNA.1 Likewise, benzazepine skeleton is a part of numerous biologically active compounds.2 Furthermore, adamantane is a very important pharmacophore that has been found in different classes of biologically active compounds.3 Therefore, it is necessary to develop new synthetic methods for the preparation of new functionalized adamantyl-heterocyclic derivatives. With the ongoing interest in our group to apply photochemical approach to the synthesis of adamantyl-heterocyclic derivatives with biological applications, 4 we have functionalized adamantanes by the phthalimide group, versatile chromophore that undergoes various photochemical reactions. Herein we describe synthesis of novel (N-phthalimido)adamantane carboxylic acid 1 and its efficient one-pot transformation to complex heterocyclic compound, adamantyl benzazepine 2, with anticipated biological activity, that is yet to be tested.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 02.05/25, 098-0982933-2911
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://www.fidelta.eu/conferences/macrocycles/
Upisao u CROSBI: Enidija Lukša (Enidija.Luksa@irb.hr), 13. Svi. 2014. u 14:46 sati



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