crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 698642

Časopis

Autori: Ballantyne, K.N.; ...; Balažić, J.; ...; Kovačević, Lejla; ...; Marjanović, Damir; ...; Onofri, Vladimir; ...; Primorac, Dragan; ...; Sharma, Anil K.; ...; Škaro, Vedrana; ...; Kayser, Manfred
Naslov: Towards male individualization with rapidly mutating Y-chromosomal STRs
Izvornik: Human mutation (1059-7794) 35 (2014), 8; 1021-1032
Vrsta rada: članak
Ključne riječi: Y-chromosome ; Y-STRs ; Rapidly mutating Y-STRs ; RM Y-STRs ; haplotypes ; microsatellites ; male lineage differentiation ; male relative differentiation ; paternal relationship ; forensic
Sažetak:
Relevant for various areas of human genetics, Y- chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17- loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14, 644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of 12, 272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919- 0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of 12, 156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), was significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% ofvariation within populations, 0.018% among populations within groups, and 0.002%among groups. Of the 2, 372 newly and 156 previously typed male relative pairs separated by 1-20 generations, 29% were differentiated including 27% of 2, 378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of populations tested ; overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
Puni text rada: 698642.2014_Human_Mutation_Ballantyne_Towards_male_individualization.pdf (tekst priložen 28. Kol. 2014. u 17:48 sati)
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1002/humu.22599/pdf
http://onlinelibrary.wiley.com/doi/10.1002/humu.22599/abstract
Broj citata:
Altmetric:
DOI: 10.1002/humu.22599
URL cjelovitog teksta:
Google Scholar: Towards male individualization with rapidly mutating Y-chromosomal STRs
Upisao u CROSBI: Vedrana Škaro (Vedrana.Skaro@irb.hr), 28. Svi. 2014. u 15:33 sati



  Verzija za printanje   za tiskati


upomoc
foot_4