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Towards male individualization with rapidly mutating Y-chromosomal STRs (CROSBI ID 206183)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ballantyne, K.N. ; ... ; Balažić, J. ; ... ; Kovačević, Lejla ; ... ; Marjanović, Damir ; ... ; Onofri, Vladimir ; ... et al. Towards male individualization with rapidly mutating Y-chromosomal STRs // Human mutation, 35 (2014), 8; 1021-1032. doi: 10.1002/humu.22599

Podaci o odgovornosti

Ballantyne, K.N. ; ... ; Balažić, J. ; ... ; Kovačević, Lejla ; ... ; Marjanović, Damir ; ... ; Onofri, Vladimir ; ... ; Primorac, Dragan ; ... ; Sharma, Anil K. ; ... ; Škaro, Vedrana ; ... ; Kayser, Manfred

engleski

Towards male individualization with rapidly mutating Y-chromosomal STRs

Relevant for various areas of human genetics, Y- chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17- loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14, 644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of 12, 272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919- 0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of 12, 156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), was significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% ofvariation within populations, 0.018% among populations within groups, and 0.002%among groups. Of the 2, 372 newly and 156 previously typed male relative pairs separated by 1-20 generations, 29% were differentiated including 27% of 2, 378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of populations tested ; overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.

Y-chromosome ; Y-STRs ; Rapidly mutating Y-STRs ; RM Y-STRs ; haplotypes ; microsatellites ; male lineage differentiation ; male relative differentiation ; paternal relationship ; forensic

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Podaci o izdanju

35 (8)

2014.

1021-1032

objavljeno

1059-7794

10.1002/humu.22599

Povezanost rada

Biologija

Poveznice
Indeksiranost