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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 709640

Časopis

Autori: Mihovilović, Karlo; Maksimović, Bojana; Kocman, Branislav; Denis Guštin, Denis; Vidas, Željko; Bulimbašić, Stela; Galešić Ljubanović, Danica; Sabljar Matovinović, Mirjana; Knotek, Mladen
Naslov: Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation : a retrospective study
( Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation : a retrospective study )
Izvornik: BMJ Open (2044-6055) 4 (2014), 7; e005005-1-e005005-
Vrsta rada: članak
Ključne riječi: transplant medicine
( transplant medicine )
Sažetak:
Chronic transplant dysfunction after kidney transplantation is a major reason of kidney graft loss and is caused by immunological and non- immunological factors. There is evidence that mycophenolate mofetil (MMF) may exert a positive effect on renal damage in addition to immunosuppression, by its direct antifibrotic properties. The aim of our study was to retrospectively investigate the role of MMF doses on progression of chronic allograft dysfunction and fibrosis and tubular atrophy (IF/TA). Setting: Retrospective, cohort study. Patients with kidney transplant in a tertiary care institution. This is a retrospective cohort study that included 79 patients with kidney and kidney- pancreas transplantation. Immunosuppression consisted of anti-interleukin 2 antibody induction, MMF, a calcineurin inhibitor±steroids. An association of average MMF doses over 1 year post-transplant with progression of interstitial fibrosis (Δci), tubular atrophy (Δct) and estimated-creatinine clearance (eCrcl) at 1 year post-transplant was evaluated using univariate and multivariate analyses. A higher average MMF dose was significantly independently associated with better eCrcl at 1  year post-transplant (b=0.21±0.1, p=0.04). In multiple regression analysis lower Δci (b=-0.2±0.09, p=0.05) and Δct (b=-0.29±0.1, p=0.02) were independently associated with a greater average MMF dose. There was no correlation between average MMF doses and incidence of acute rejection (p=0.68). A higher average MMF dose over 1  year is associated with better renal function and slower progression of IF/TA, at least partly independent of its immunosuppressive effects.
Projekt / tema: 044-0000000-3356, 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://bmjopen.bmj.com/content/4/7/e005005.long
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091392/
Broj citata:
Altmetric:
DOI: 10.1136/bmjopen-2014-005005
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation : a retrospective study
Upisao u CROSBI: Danica Ljubanović (danica.ljubanovic@zg.t-com.hr), 10. Kol. 2014. u 11:40 sati



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