Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 717636

Zbornik radova

Autori: Krištić, Jasminka; Vučković, Frano; Menni, Cristina; Klarić, Lucija; Keser, Toma; Beceheli, Ivona; Pučić-Baković, Maja; Novokmet, Mislav; Mangino, Massimo; Thaqi, Kujtim; Rudan, Pavao; Novokmet, Natalija; Šarac, Jelena; Missoni, Saša; Kolčić, Ivana; Polašek, Ozren; Rudan, Igor; Campbell, Harry; Hayward, Caroline; Aulchenko, Yurii; Valdes, Ana; Wilson, James F; Gornik, Olga; Primorac, Dragan; Zoldoš, Vlatka; Lauc, Gordan
Naslov: Glycans are a novel biomarker of chronological and biological age
Izvornik: Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014 / Katalinić, Maja ; Kovarnik, Zrinka (ur.). - Croatian Society of Biochemistry and Molecular Biology , 2014. 103-103 (ISBN: 978-953-95551-5-1).
Skup: The Interplay of Biomolecules, HDBMB2014
Mjesto i datum: Zadar, Zagreb, 24-27.09.2014.
Ključne riječi: Aging ; Glycome ; Glycosylation ; Immunoglobulin G ; Inflammation
Sažetak:
Fine structural details of glycans attached to the conserved N-glycosylation site significantly affect function of individual IgG molecules, but also mediate inflammation at the systemic level. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very complex patterns of changes of IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Izvorni jezik: ENG
Kategorija: Ostalo
Znanstvena područja:
Biologija
Upisao u CROSBI: Toma Keser (tkeser@pharma.hr), 29. Ruj. 2014. u 16:18 sati