crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 718355

Zbornik radova

Autori: Cindrić, Marina; Tartaro Bujak, Ivana; Čipak, Ana; Milković, Lidija; Mihaljević, Branka; Žarković, Neven; Žarković, Kamelija
Naslov: 4-Hydroxynonenal and linoleic acid micelles can modulate permeability of an in vitro blood-brain barrier
Izvornik:
Skup: Joint Meeting: 7th HNE-Club International Meeting & 5th Health Food Symposium - SAS 2014
Mjesto i datum: Toulouse, Francuska, 08.-10.09.2014.
Ključne riječi: blood-brain barrier; hydroxynonenal; linoleic acid; permeability
Sažetak:
Blood-brain barrier (BBB) represents the main obstacle to the effective treatment of central nervous system (CNS) diseases. Even though lipid peroxidation end products are recognized as important factors in the development and onset of numerous neurodegenerative diseases, their role still needs to be clarified. In the field of brain tumors, 4-hydroxynonenal (HNE) is the most intensively studied aldehyde. It was proven as a valuable prognostic factor in astrocytomas. Besides, co-expression of HNE and CD133 in brain tumor cells, mesenchymal stroma and blood vessels emphasizes the role of HNE in tumor propagation into higher grade. Accelerated CNS tumor progression can be a consequence of increased BBB integrity, thus being aggravating factor in disease treatment. Equally, controlled increase of BBB permeability would result in easier drug flow to the brain. Hence, HNE and micelles of linoleic acid (a major source of essential arachidonic acid in the brain) were used in order to modulate permeability and integrity of BBB in vitro model. The model comprised rat brain endothelial cells (RbE4 cell line) and astrocytes grown on opposite sides of cell culture insert. Changes in permeability and integrity of BBB model were observed through TEER (trans endothelial electrical resistance) measurement and sodium fluorescein passage. Antioxidative status and lipid peroxidation were also assessed. Lipid profiles of the endothelial cells exposed to different treatments were determined. Results revealed that BBB integrity and permeability can be effectively modulated by HNE and linoleic acid micelles. These treatments caused changes in amounts of HNE-modified proteins present in cells constituting the BBB. Antioxidative status of these cells was also affected due to treatments.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Kategorija: Znanstveni
Upisao u CROSBI: Marina Štoser (mstroser@mef.hr), 2. Lis. 2014. u 11:29 sati



Verzija za printanje   za tiskati


upomoc
foot_4