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Pulmonary nontuberculous mycobacterial disease in Croatia (CROSBI ID 615459)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Janković, Mateja ; Jakopović, Marko ; Sabol, Ivan ; Zmak, Ljiljana ; Katalinić Janković, Vera, Popović-Grle, Sanja ; Tićac, B ; Redžepi, Gzim ; Bulat Kardum, Ljiljana ; Samaržija, Miroslav Pulmonary nontuberculous mycobacterial disease in Croatia // Zbornik radova Toraks 2014. Zagreb: Hrvatsko torakalno društvo, 2014. str. P-12-P-12

Podaci o odgovornosti

Janković, Mateja ; Jakopović, Marko ; Sabol, Ivan ; Zmak, Ljiljana ; Katalinić Janković, Vera, Popović-Grle, Sanja ; Tićac, B ; Redžepi, Gzim ; Bulat Kardum, Ljiljana ; Samaržija, Miroslav

engleski

Pulmonary nontuberculous mycobacterial disease in Croatia

Objective: Epidemiology and clinical relevance of isolation of nontuberculous mycobacteria (NTM) in Croatia are largely unknown. We aimed to measure the isolation rate of NTM species obtained from pulmonary samples, record geographical differences, assess the clinical relevance of different NTM species, and burden of pulmonary NTM disease (PNTM). Methods: Retrospective analysis of all Croatian residents with NTM isolated in the period from 2006 through 2012. Microbiological and whole criteria of the American Thoracic Society (ATS) were used to establish a case definition of PNTM. Result: NTM species were isolated from 1613 individuals. The most frequently isolated NTM species were Mycobacterium gordonae and M. xenopi. Average annual incidence of NTM isolation was 3.9/100 000. M. avium (p<0.001) and M. xenopi (p<0.0001) were more frequent in coastal region, and M. gordonae (p<0.0001) and M. terrae (p<0.0005) in the continental region. We reviewed medical records for over 26% of all isolates and found good correlation between the microbiological and the whole ATS criteria. Most cases of PNTM were caused by M. xenopi and M. avium complex. We estimated the average annual incidence of PNTM at 0.32/100 000 in TORAKS 2014 - 4. kongres Hrvatskog torakalnog društva Zagreb, 4 - 7. 6. 2014. the coastal and 0.16/100 000 in the continental region. The overall annual incidence of PNTM amounts to 0.22/100 000 which represents a four-fold increase compared to the previous 5 year period. The incidence of the PNTM increases with age, and in persons over 50 years amounts to 0.5/100 000. Of all symptoms and risk factors, only haemoptysis and low body mass index are significantly connected with PNTM compared to colonization of respiratory tract. Most commonly found co-morbidities in patients with PNTM are COPD, bronchiectasis and prior history of tuberculosis. In Croatia, nodular-bronchiectatic type of disease prevails over cavitary type, while treatment of PNTM significantly deviates from the ATS guidelines. Conclusion: The incidence of PNTM in Croatia is increasing, but overall burden of PNTM is still low compared to tuberculosis. Geography plays a role in NTM species distribution in Croatia, and the burden of the disease is higher in the coastal compared to the continental region. We found good correlation between the microbiological and the whole ATS criteria in the estimation of the PNTM incidence. There is a clear need to increase both knowledge and awareness about PNTM among respiratory physicians in Croatia.

Nontuberculous mycobacterial infections

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

P-12-P-12.

2014.

objavljeno

Podaci o matičnoj publikaciji

Zbornik radova Toraks 2014

Zagreb: Hrvatsko torakalno društvo

Podaci o skupu

Toraks 2014 : 4. Kongres Hrvatskog torakalnog društva s međunarodnim sudjelovanjem = Thorax 2014 : 4th Congress of the Croatian Thoracic Society with international participation, Zagreb, 4. – 7. 6 2014, Zagreb

poster

04.07.2014-04.07.2014

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti