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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 724890

Časopis

Autori: Novak, Anita; Goić Barišić, Ivana; Tambić Andrasević, Arjana; Butić, Iva; Radić, Marina, Jelić, Marko; Rubić, Žana; Tonkić, Marija
Naslov: Monoclonal Outbreak of VIM-1-Carbapenemase- Producing Enterobacter cloacae in Intensive Care Unit, University Hospital Centre Split, Croatia
( Monoclonal Outbreak of VIM-1-Carbapenemase- Producing Enterobacter cloacae in Intensive Care Unit, University Hospital Centre Split, Croatia )
Izvornik: Microbial drug resistance-mechanisms epidemiology and disease (1076-6294) 20 (2014), 5; 399-403
Vrsta rada: članak
Ključne riječi: Enterobacter cloacae; VIM-1; carbapenem resistant; outbreak
( Enterobacter cloacae; VIM-1; carbapenem resistant; outbreak )
Sažetak:
Emergence of carbapenem-resistant Enterobacteriaceae has become a substantial global health problem. The aim of this study was to analyze carbapenem-resistant isolates of Enterobacter cloacae that have emerged for the first time in the intensive care unit (ICU) at the University Hospital Centre Split, Croatia. The strains were selected in the period between June and August 2012, according to their susceptibility patterns to carbapenems. Resistant isolates were screened for metallo-β- lactamase (MBL) production with the use of the imipenem-EDTA disk synergy test, and positive findings were confirmed by PCR. The type of VIM β-lactamase gene was determined by sequencing of PCR products. The genetic relatedness was evaluated using pulsed-field gel electrophoresis analysis. The demographic and clinical data were retrospectively analyzed from medical records. Five patients were infected and one patient was colonized with a single clone of multidrug-resistant VIM-1- producing E. cloacae susceptible only to colistin. Three cases of lower respiratory tract infections, one case of bacteremia, and one case of intra-abdominal infection were identified. All cases were hospital-acquired after prolonged stay in ICU. All patients had serious underlying diseases and received a broad-spectrum antibiotic. Four patients died and two had unimprovable medical condition at the time of discharge from the hospital. MBL- producing E. cloacae can cause fatal infection in severely ill patients. Monoclonal outbreak highlights the need for continuous surveillance and good infection control practices to prevent further spread since the antibiotic therapy options for infections caused by such strains are strongly limited.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://online.liebertpub.com/doi/abs/10.1089/mdr.2013.0203
Broj citata:
Altmetric:
DOI: 10.1089/mdr.2013.0203
URL cjelovitog teksta:
Google Scholar: Monoclonal Outbreak of VIM-1-Carbapenemase- Producing Enterobacter cloacae in Intensive Care Unit, University Hospital Centre Split, Croatia
Upisao u CROSBI: Ivana Goić Barišić (ivanagoicbar@net.hr), 30. Lis. 2014. u 09:59 sati



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