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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 728061

Časopis

Autori: Kuzmanić Šamija, Radenka; Primorac, Dragan; Rešić, Biserka; Pavlov, Vesna; Čapkun, Vesna; Punda, Hrvoje; Lozić, Bernarda; Zemunik, Tatijana
Naslov: Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy
Izvornik: Brazilian journal of medical and biological research (0100-879X) 47 (2014); 869-875
Vrsta rada: članak
Ključne riječi: Clinical contributors; Hypoxic-ischemic encephalopathy; NOS3 gene polymorphisms
Sažetak:
The aim of this study was to analyze the association of different clinical contributors of hypoxic-ischemic encephalopathy with NOS3 gene polymorphisms. A total of 110 children with hypoxic-ischemic encephalopathy and 128 control children were selected for this study. Association of gender, gestational age, birth weight, Apgar score, cranial ultrasonography, and magnetic resonance imaging findings with genotypic data of six haplotype-tagging single nucleotide polymorphisms and the most commonly investigated rs1800779 and rs2070744 polymorphisms was analyzed. The TGT haplotype of rs1800783, rs1800779, and rs2070744 polymorphisms was associated with hypoxic-ischemic encephalopathy. Children with the TGT haplotype were infants below 32 weeks of gestation and they had the most severe brain damage. Increased incidence of the TT genotype of the NOS3 rs1808593 SNP was found in the group of hypoxic-ischemic encephalopathy patients with medium and severe brain damage. The probability of brain damage was twice as high in children with the TT genotype than in children with the TG genotype of the same polymorphism. Furthermore, the T allele of the same polymorphism was twice as frequent in children with lower Apgar scores. This study strongly suggests associations of NOS3 gene polymorphism with intensity of brain damage and severity of the clinical picture in affected children.
Projekt / tema: 216-1080315-0293
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy
Upisao u CROSBI: Tatijana Zemunik (tatijana.zemunik@mefst.hr), 7. Stu. 2014. u 14:42 sati



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