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Pregled bibliografske jedinice broj: 72820

Časopis

Autori: Stančić-Rokotov, Dinko; Slobodnjak, Zoran; Aralica, Josip; Aralica, Gorana; Perović, Darko; Starešinić, Mario; Gjurašin, Miroslav; Anić, Tomislav; Zoričić, Ivan; Buljat, Gojko; Prkačin, Ingrid; Sikirić, Predrag; Seiwerth, Sven; Ručman, Rudolf; Petek, Marijan; Turković, Branko; Kokić, Neven; Jagić, Vjekoslav; Boban-Blagaić, Alenka
Naslov: Lungs lesions and anti-ulcer agents beneficial effect:Anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats
( Lungs lesions and anti-ulcer agents beneficial effect:Anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats )
Izvornik: Journal of Physiology-Paris 95 (2001); 303 - 308
Vrsta rada: članak
Ključne riječi: Lung lesion; Anti-ulcer agents; Amelioration of lung lesion; Direct cytoprotective effect
( Lung lesion; Anti-ulcer agents; Amelioration of lung lesion; Direct cytoprotective effect )
Sažetak:
Anti-ulcer agents may likely attenuate lesions outside the gastrointestinal tract, since they had protected gastrectomized rats (a "direct cytoprotective effect"). Therefore, their therapeutic potential in lung/stomach lesions were shown. Rats recived an intratracheal (i.t.) HCl instillation ((1.5 ml/kg HCl (pH 1.75)) (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion ; 1 ml/rat, 24 h after i.t. HCl instillation), than sacrificed 1 h after ethanol. Basically, in lung-injured rats, the subsequent ethanol-gastric lesion was markedly aggravated.This aggravation, however, in turn, did not affect the severity of the lung lesions in the further period, at least for 1 h of observation. Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microgram, 10 nanogram, 10 picogram), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg), were given ((/kg, intraperitoneally (i.p.) )) (i) once, only prophylactically ((as a pre-treatment (at - 1 h) )), or as a co-treatment ((at 0)), or only therapeutically (at + 18 h or + 24 h) ; (ii) repeatedly, combining prophylactic/therapeutic regimens (( (- 1h)+(+24h) )) or (( (0)+ (+24h) )), or therapeutic/therapeutic regimens (( (+18h)+(+24h) )). For all agents, combining their prophylactic and salutary regimens (at - 1h/24h, or at 0/+24hh) attenuated lung lesions ; even if effect had been not seen alreadly whit a single application, it became prominent after repeated treatment.In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at - 1h) (pentadecapeptide BPC 157 and atropine, but not ranitidine and omeprazole) regulary attenuated, while therapeutically, atropine (at +18h), pentadecapeptide BPC 157 highest dose and omeprazole at +24h), reversed the otherwise more severe lung lesion.
Projekt / tema: 0108196
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Lungs lesions and anti-ulcer agents beneficial effect:Anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats



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