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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 728664

Časopis

Autori: Pattaro, C.; ...; Gorski, M.; ...; Glazer, N.; ...; ...; Kolčić, Ivana; Zemunik, Tatjana; Boban, Mladen; ...; Polašek, Ozren; ...; Rudan, Igor; ...; Fox, C.S.
Naslov: Genome-wide association and functional follow-up reveals new loci for kidney function
( Genome-wide association and functional follow-up reveals new loci for kidney function )
Izvornik: Plos genetics (1553-7390) 8 (2012), 3; e1002584
Vrsta rada: članak
Ključne riječi: CKD; genetic; mpped2; casp9
( CKD; genetic; mpped2; casp9 )
Sažetak:
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130, 600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.ncbi.nlm.nih.gov/pubmed/22479191
Broj citata:
Altmetric:
DOI: 10.1371/journal.pgen.1002584
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Genome-wide association and functional follow-up reveals new loci for kidney function
Upisao u CROSBI: Mladen Boban (mladen.boban@mefst.hr), 10. Stu. 2014. u 13:02 sati
Napomene:
CARDIoGRAM Consortium ; ICBP Consortium ; CARe Consortium ; Wellcome Trust Case Control Consortium 2 (WTCCC2).



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