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Pregled bibliografske jedinice broj: 733445

Zbornik radova

Autori: Ozkok, Abdullah; Ravichandran, Kameswaran; Nguyen, Quocan, Wang, Qian; Galešić Ljubanović, Danica; Edelstein, Charles L.
Naslov: NFKB Inhibition Protects against Cisplatin-Induced Acute Kidney Injury
( NFKB Inhibition Protects against Cisplatin-Induced Acute Kidney Injury )
Izvornik: J Am Soc Nephrol
ISSN: 1046-6673
Skup: ASN Kidney Week 2014
Mjesto i datum: Philadelphia, SAD, 11-16.11.2014
Ključne riječi: NFKB; Cisplatin-Induced Acute Kidney Injury
( NFKB; Cisplatin-Induced Acute Kidney Injury )
Sažetak:
Background: NFKB is a cell signaling pathway important in inflammation and cell survival. Inflammation, acute tubular necrosis (ATN) and apoptosis in the kidney are features of cisplatin-induced AKI. The role of NFKB in cisplatin-induced AKI was determined. Methods: C57BL/6 miceinjected were with cisplatin (Cis) (25 mg/kg) get AKI on day 3. The NFKB (p65) inhibitor JSH-23 (20 mg/kg)IP was injected on day 1 and 2 after cisplatin. Results: Kidney function (BUN, SCr), tubular injury (ATN, serum NGAL), pro- inflammatory cytokines (IL-6, CXCL1, TNF alpha) and MPO activity (a marker of neutrophils and macrophages) were significantlyincreased in AKI and decreased by JSH. On immunoblotof kidney tissuesNFKB (p65), MEKK-1, ERK, JNK, cleaved caspase-3 were significantly increased in AKI and significantly decreased by JSH-23 (n=4 immunoblots/group. Statistical analysis of densitometry data was performed. Conclusions: NFKB inhibition protects against Cis-induced AKI, decreases ATN but not apoptosis, decreases MAPK pathway proteins and pro- inflammatory cytokines and MPO.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: https://www.asn-online.org/education/kidneyweek/archives/
Upisao u CROSBI: Danica Ljubanović (danica.ljubanovic@zg.t-com.hr), 24. Stu. 2014. u 19:46 sati



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