Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Possible implications of TGF-alpha in eosophageal dysmotility in systemic sclerosis (CROSBI ID 212450)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lalovac, Miloš ; Martinović Kaliterna, Dušanka ; Mejić Krstulović, Stanka ; Marković, Vinko ; Salamunić, Ilza ; Perković, Dijana Possible implications of TGF-alpha in eosophageal dysmotility in systemic sclerosis // Clinical and experimental rheumatology, 32 (2014), S86; S149-S153

Podaci o odgovornosti

Lalovac, Miloš ; Martinović Kaliterna, Dušanka ; Mejić Krstulović, Stanka ; Marković, Vinko ; Salamunić, Ilza ; Perković, Dijana

engleski

Possible implications of TGF-alpha in eosophageal dysmotility in systemic sclerosis

OBJECTIVES: Hypoxia is a characteristic feature of systemic sclerosis (SSc).Transforming growth factor alpha (TGF-α) has an important role in excessive inflammation under hypoxic conditions. Since oesophageal dysmotility is one of the most common signs of SSc, the aim of this study was to explore the relation between TGF-α and oesophageal dysmotility in SSc. METHODS: The study included 35 patients with SSc and 32 healthy controls matched for sex and age. Serum concentrations of TGF-α were measured using ELISA. Oesophageal motility was assessed by oesophageal scintigraphy. A multiple-swallow test was performed in the study population with 99mTc-DTPA. A region of interest over the entire oesophagus was defined and the retention index (RI) was calculated. RESULTS: Statistically significant differences in serum concentration of TGF-α as well as of RI of 99mTc-DTPA were found between patients with SSc and healthy controls. A statistically significant correlation was found between serum concentrations of TGF-α and RIs of 99mTc-DTPA. This correlation was inverse, i.e. when serum concentrations of TGF-α increased, the RI of 99mTc-DTPA decreased (Spearman rho =-0361, p=0.033). CONCLUSIONS: These results point to a possible relation between TGF-α and oesophageal dysmotility in SSc. Although the results do not explain the exact role of this cytokine in the pathogenesis of esophageal changes, the finding of inverse correlation between TGF-α and oesophageal dysmotility is intriguing and requires further investigation.

systemic sclerosis; TGF-α

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

32 (S86)

2014.

S149-S153

objavljeno

0392-856X

Povezanost rada

nije evidentirano

Indeksiranost