Combined auxiliary split liver and kidney transplantation for type I primary hyperoxaluria and end-stage kidney disease (CROSBI ID 212608)
Prilog u časopisu | Pismo (znanstveno) | međunarodna recenzija
Podaci o odgovornosti
Knotek, Mladen ; Maksimović, Bojana ; Gunjača, Mihaela ; Mihovilović, Karlo ; Galešić Ljubanović, Danica ; Kocman, Branislav
engleski
Combined auxiliary split liver and kidney transplantation for type I primary hyperoxaluria and end-stage kidney disease
Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease, caused by loss of function in liver-specific alanine-glyoxylate aminotransferase (AGT). Accumulation of oxalate in PH1 causes nephrocalcinosis and urolithiasis leading to end-stage kidney (ESKD) in 90% of patients.1 These patients are treated by combined liver and kidney transplantation (LKT). Liver transplantation (LT) in PH1 has traditionally been performed as an orthotopic whole LT.2 Combined auxiliary LKT may mitigate the risk of whole LT, because native liver is preserved.
liver and kidney transplantation ; type I primary hyperoxaluria ; end-stage kidney disease
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti