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Pregled bibliografske jedinice broj: 73645

Zbornik radova

Autori: Šimić, Goran
Naslov: The role of programmed cell death in Werdnig-Hoffmann disease
Izvornik: The First Summer School of Croatian Institute for Brain Research 'Brain Development, Injury and Repair', Zagreb, 5-7. VII 1999.Zagreb :
Skup: The First Summer School of Croatian Institute for Brain Research 'Brain Development, Injury and Repair', Zagreb, 5-7. VII 1999.
Mjesto i datum: Zagreb, Hrvatska, 5-7.07.1999.
Ključne riječi: spinal muscular atrophy; pathogenesis; apoptosis
Sažetak:
The development of the vertebrate nervous system is characterized by an initial overproduction of neurons in many regions followed by large-scale elimination. It is esimated that, immediately following the arrival of their axons in muscle cells, about 40-70% of the embryonic motor neurons in the spinal cord undergo naturally occurring programmed cell death during the midgestational period (15-25 weeks of gestation in the human fetus). The hypothesis that spinal muscular atrophies, particularly Werdnig-Hoffmann disease or SMA type-1, is based on an inappropriate persistence of normally occurring apoptosis is presented and discussed with respect to recent genetic and neuropathological results from our and other laboratories.
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 108118
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti



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