crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 73650

Zbornik radova

Autori: Šimić, Goran
Naslov: Cell death in Alzheimer's disease
Izvornik: The 10th 'Ljudevit Jurak' International Symposium on Comparative Pathology, Zagreb, 4-5. VI 1999.Zagreb :
Skup: The 10th 'Ljudevit Jurak' International Symposium on Comparative Pathology, Zagreb, 4-5. VI 1999.
Mjesto i datum: Zagreb, Hrvatska, 4-5.06. 1999.
Ključne riječi: cell death; Alzheimer's disease; apoptosis; necrosis
Sažetak:
On the basis of in-situ end labeling, in vitro results and immunocytochemistry for apoptosis-related proteins, several authors have suggested that apoptosis occurs in Alzheimer's disease. However, the present investigations of our and many other laboratories found only necrotic morphology of ISEL- and TUNEL-positive neurons in Alzheimer's disease, which agrees with the known time kinetics of apoptotic cell death. As it has been calculated that apoptotic morphology is present for only a few hours in the brain, ranging from 3 to 72 h, should very large numbers of cells per thin section of a chronic disease like Alzheimer's be present, this would imply that the entire structure would be fully degenerated in days, which is very unlikely. This also suggest that not apoptosis, but necrosis and increased DNA vulnerability are major phenomena in postmortem Alzheimer's disease brain.
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 108118
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti



  Verzija za printanje   za tiskati


upomoc
foot_4