crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 73651

Zbornik radova

Autori: Šimić, Goran
Naslov: Abnormal polysialylation in spinal muscular atrophy: Clues for possible new role of the survival motor neuron protein
Izvornik: Meeting of the biochemistry and molecular biology group, Multi-disciplinary research and innovation centre, North East Wales InstituteWrexham :
Skup: Meeting of the biochemistry and molecular biology group, Multi-disciplinary research and innovation centre, North East Wales Institute
Mjesto i datum: Wrexham, United Kingdom, 07.06. 001.
Ključne riječi: neural cell adhesion molecules; neuronal migration; spinal muscular atrophy
Sažetak:
Spinal muscular atrophy (SMA) is a common autosomal recessive disease characterized by the loss of spinal motor neurons that result from mutations in the Survival of Motor Neuron (SMN) gene. The function of SMN gene is largely unknown. Although involved in pre-mRNA splicing and spliceosomal snRNP biogenesis, this regulatory function cannot explain why only specific neuronal populations in spinal cord, brainstem and dorsal root ganglia degenerate in SMA patients, while other cell types remain unaffected. One of the major neuropathological hallmarks of acute SMA (SMA1) is a failure of lower motoneurons to synapse homophylically with axons of the upper motor neurons, resulting in their abnormal migration towards anterior spinal roots. Since the sugar components of glycoconjugates of cell membranes are responsible for cell adhesion and recognition processes which play a key role during migration, in a pilot study we tried to assess the post-translational modifications of neuronal cell adhesion molecule (NCAM) and other proteins due to glycosylation in the brain tissue from patients with SMA1, normal age-matched and adult controls. Preliminary results and plans for future research were presented and discussed.
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Nije objavljen
Vrsta recenzije: Nema recenziju
Projekt / tema: 108118
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Napomene:
220 ALIS-British Council



  Verzija za printanje   za tiskati


upomoc
foot_4