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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 738806

Časopis

Autori: Milković, Lidija; Siems, Werner; Siems, Renate; Žarković, Neven
Naslov: Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Izvornik: Current pharmaceutical design (1381-6128) 20 (2014), 42; 6529-6542
Vrsta rada: pregledni rad
Ključne riječi: Oxidative stress; reactive oxygen species (ROS); lipid peroxidation; carcinogenesis; redox signaling; anoikis; antioxidants; therapy
Sažetak:
Oxidative stress is often considered as a causative factor in carcinogenesis. In addition, current knowledge recognizes oxidative stress as a mechanism by which various cancer therapies act against cancer. To ameliorate the side effects of cancer therapy, many of the patients suffering from cancer are subject to adjuvant therapy, which often implies antioxidant supplementation. Yet, the benefits of such adjuvant treatments are still uncertain owing to the lack of appropriate integrative and personalized medical approach. In particular, reactive oxygen species formed during oxidative stress and products of lipid peroxidation are not only cytotoxic, but can modulate signal transduction in cells, which also behave similar to individuals under stress. Accordingly, pro-oxidants and antioxidants might be considered as modifiers of specific cellular redox signaling. Therefore, there is a need to evaluate the potential benefits of antioxidant supplements in healthy persons, and in particular in cancer patients during therapy. Our review will present a summary of the existing knowledge regarding the effects of various antioxidants in cancer therapies, focusing on cellular adaptation to oxidative stress interacting with redox signaling transduction pathways thereby influencing cell growth.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://www.ingentaconnect.com/contentone/ben/cpd/2014/00000020/00000042/art00004
URL cjelovitog teksta:
Google Scholar: Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Upisao u CROSBI: Marina Štoser (mstroser@mef.hr), 8. Pro. 2014. u 09:44 sati



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