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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 739866

Časopis

Autori: Sabol, Maja; Trnski, Diana; Užarević, Zvonimir; Ozretić, Petar; Musani, Vesna; Rafaj, Maja; Cindrić, Mario; Levanat, Sonja
Naslov: Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways
( Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways )
Izvornik: PLOS ONE (1932-6203) 9 (2014), 12; e114510-1-e114510-23
Vrsta rada: članak
Ključne riječi: PTCH1; Gli1; sonic hedgehog; estrogen receptor; breast cancer
( PTCH1; Gli1; sonic hedgehog; estrogen receptor; breast cancer )
Sažetak:
Hedgehog-Gli (Hh-Gli) signaling pathway is one of the new molecular targets found upregulated in breast tumors. Estrogen receptor alpha (ERα) signaling has a key role in the development of hormone-dependent breast cancer. We aimed to investigate the effects of inhibiting both pathways simultaneously on breast cancer cell survival and the potential interactions between these two signaling pathways. ER-positive MCF-7 cells show decreased viability after treatment with cyclopamine, a Hh-Gli pathway inhibitor, as well as after tamoxifen (an ERα inhibitor) treatment. Simultaneous treatment with cyclopamine and tamoxifen on the other hand, causes short-term survival of cells, and increased migration. We found upregulated Hh-Gli signaling under these conditions and protein profiling revealed increased expression of proteins involved in cell proliferation and migration. Therefore, even though Hh-Gli signaling seems to be a good potential target for breast cancer therapy, caution must be advised, especially when combining therapies. In addition, we also show a potential direct interaction between the Shh protein and ERα in MCF-7 cells. Our data suggest that the Shh protein is able to activate ERα independently of the canonical Hh-Gli signaling pathway. Therefore, this may present an additional boost for ER-positive cells that express Shh, even in the absence of estrogen
Projekt / tema: 098-0982464-2461
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/2051/1/journal.pone.0114510.pdf
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114510
Broj citata:
Altmetric:
DOI: 10.1371/journal.pone.0114510
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways
Upisao u CROSBI: Sonja Levanat (Sonja.Levanat@irb.hr), 10. Pro. 2014. u 15:54 sati



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