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Pregled bibliografske jedinice broj: 741023

Časopis

Autori: Mahovic, Darija; Zurak, N; Lakusic, N; Sporis, D; Žarkovic, Neven; Stancin, N; Bosnar-Puretic M
Naslov: The dynamics of soluble Fas/APO 1 apoptotic biochemical marker in acute ischemic stroke patients
Izvornik: Advances in medical sciences (1896-1126) 58 (2013); 298-303
Vrsta rada: članak
Ključne riječi: acute ischemic stroke ; Fas/APO 1
Sažetak:
PURPOSE: Until recently, neuronal death in ischemic stroke infarction was ascribed exclusively to necrotic process. However, experimental animal models of cerebral ischemia suggest apoptosis to play a role in the pathogenesis of cerebral infarction. The aim of this study was to determine the level and monitor the dynamics of soluble Fas/APO 1 (sFas/APO 1) in serum and cerebrospinal fluid of acute ischemic stroke patients. MATERIAL AND METHODS: This prospective study included 23 patients with first ever, computed tomography verified acute ischemic stroke and 20 control subjects with other functional neurologic disorders. Serum and cerebrospinal fluid sFas/APO 1 levels were determined on several occasions. Blood samples were obtained on day 1, 3 and 12, and lumbar puncture on day 3 and 12 of disease onset. Quantitative sandwich ELISA method was used on sFas/APO 1 determination. RESULTS: On day 1 of disease onset, serum and cerebrospinal fluid sFas/APO 1 levels were significantly higher in stroke patients as compared to control subjects, and then gradually declined during the period of monitoring. CONCLUSION: Study results confirmed the dynamic pattern of sFas/APO 1 in serum and cerebrospinal fluid of patients with acute ischemic stroke, suggesting the possible role of apoptosis in the pathogenesis of cerebral infarction.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1896112614602030
Broj citata:
Altmetric:
DOI: 10.2478/ams-2013-0014
URL cjelovitog teksta:
Google Scholar: The dynamics of soluble Fas/APO 1 apoptotic biochemical marker in acute ischemic stroke patients
Upisao u CROSBI: Marina Štoser (mstroser@mef.hr), 15. Pro. 2014. u 10:24 sati



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